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The Gordon Wilson Lectures 1937 Warfield T. Longscope, M.D. Some Observations on the Course and Outcome of Hemorrhagic Nephritis. 1938 Henry A. Christian, M.D. A Glomerular Dominance in Bright’s Disease. 1939 George R. Minot, M.D. Anemias of Nutritional Deficiency. 1940 Rollin T. Woodyatt, M.D. On the Theory of Diabetes. 1941 Alfred Blalock, M.D. Shock of Peripheral Circulatory Failure. 1946 Rene J. DuBos, Ph.D. The Experimental Analysis of Tuberculous Infections. 1947 Cecil James Watson, M.D. Some Aspects of the Prophyrin Problem in Relation to Clinical Medicine. 1948 Hans Selye, M.D. General-Adaptation Syndrome. 1949 Joseph E. Smadel, M.D. The Changing Status of the Rickettsoises. 1950 Wilder Penfield, M.D. The Mechanism of Memory. 1951 Andre Cournand, M.D. Clinical and Physic-Pathologic Considerations in Certain Types in Pulmonary Granulomata and Fibrosis. 1952 Joseph Stokes, Jr., M.D. Viral Hepatitis. 1953 George W. Thorn, M.D. Studies on the Adrenal Cortical Response to Stress in Man. 1954 Allen O. Whipple, M.D. The Splenic Circulation in Relation to Certain of the Splenopathies. 1955 John F. Enders, Ph.D. Observations on Certain Viruses Causing Exanthematous Diseases in Man. 1956 Lee E. Enders, Ph.D. Man, Medicine and the Atom. 1957 Joseph W. Ferrebee, M.D. Factors Affecting the Survival of Transplanted Tissues. 1958 Ivan L. Bennett, M.D. Fever: Experimental Studies. 1959 Raymond D. Adams, M.D. Nutritional Diseases of the Nervous System in the Alcoholic Patient. 1960 Arnold R. Rich, M.D. Visceral Hazards of Hypersensitivity to Drugs. 1961 William B. Castle, M.D. A Century of Curiosity about Pernicious Anemia. 1962 Jerome W. Conn, M.D. Some Clinical and Climatological Aspects of Aldosteronism in Man. 1963 Albert H. Coons, M.D. Current Theories of Antibody Formation. 1964 Joseph F. Ross, M.D. Ionizing Radiation and the Development and Survival of Life. 1965 Alfred Gellhorn, M.D. Clinical and Laboratory Aspects of Medical Oncology. 1966 E. B. A. Astwood, M.D., Ph.D. Growth Hormones—1966. 1967 Robert A. Good, Ph.D., M.D., and Joanne Finstad, M.D. The Development and Involution of the Lymphoid System and Immunologic Capacity. 1968 Tinsley R. Harrison, M.D. Heart Disease and Heart Failure: Some Recent Progress and Some Future Challenges. 109

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1969 Eric K. Cruickshank, M.D. Clinical Syndromes Associated with Plant Toxins in Jamaica. 1970 James G. Hirsch, M.D. The Digestive Tract of Cells. 1971 Albert L. Lehninger, Ph.D. Mitochondria and the Physiology of Ca2½ 1972 Eugene Braunwald, M.D. Investigations on Protection of the Ischemic Myocardium. 1973 G. D. Aurbach, M.D. Biosynthesis, Secretion and Mechanisms of Action of Parathyroid Hormone. 1974 Robert S. Schwartz, M.D. Searching for the Cause of Systemic Lupus Erythematosus. 1975 J. Fraser Mustard, M.D. The Function of Blood Platelets. 1976 Allan L. Goldstein, Ph.D. The History of the Development of Thymosin: Chemistry, Biology, and Chemical Applications 1977 Theodore T. Puck, Ph.D. The New Cell Biology and its Implications for Medicine. 1978 Christian J. Lamberston, M.D. Undersea Medicine—The Limits of Human Tolerance. 1979 Daniel Nathans, M.D. The New Genetics. 1980 Richard T. Johnson, M.D. Viruses and Chronic Neurological Diseases. 1981 Russell Ross, M.D. Atherosclerosis—A Response to Injury Gone Awry. 1982 Robert J. Lefkowitz, M.D. Adrenergic Receptors: Regulation at the Biochemical, Physiological and Clinical Levels. 1983 Paul E. Lacy, M.D. The Prevention of Immune Rejection of Islet Transplants without Immunosuppressive Drugs. 1984 Hilary Koprowski, M.D. Monoclonal Antibodies in Human Cancer. 1985 Baruch S. Blumberg, M.D. The Biology of Hepatitis B Virus. 1986 Barry M. Brenner, M.D., and Sharon Anderson, M.D. Why Kidneys Fail: An Unifying Hypothesis. 1987 Vernon B. Mountcastle, M.D. Representations and the Construction of Reality. 1988 Darwin J. Prockop, M.D., Ph.D. Collagen. A Vulnerable Gene Protein-System. 1989 Lewis T. Williams, M.D. Growth Factors and Their Receptors—A Proliferating Field. 1990 Maria I. New, M.D. Congenital Adrenal Hyperplasia. 1991 Saul Krugman, M.D. The ABC’s of Viral Hepatitis. 1992 Waldo R. Fiser, M.D., Ph.D. Plasma Cholesterol: Atherogenesis and Mortality. 1993 Perry V. Halushka, M.D., Ph.D. Regulation of Thromboxane A2 Receptors by Testosterone: Implications for Steroid Abuse and Cardiovascular Disease. 1994 Ronald G. Crystal, M.D. In Vivo Gene Therapy: A Strategy to Use Human Genes as Therapeutics. 1995 Diane E. Griffin, M.D., Ph.D. Unique Interactions Between Viruses, Neurons and the Immune System. 110

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1996 Gerry S. Oxford, Ph.D. Decade of the Brain: Advances and Hopes at the Midpoint. 1997 Mary Lee Vance, M.D. Growth Hormone Replacement in Adults and Other Uses. 1998 Kenneth I. Berns, M.D. From Basic Virology to Human Gene Therapy. 1999 Peter T. Scardino, M.D. Natural History and Treatment of Early Stage Prostate Cancer. 2000 Gary J. Nabel, M.D. Viruses and Human Disease. 2001 Richard M. Weinshilboum, M.D. The Mayo Model: One Path to an Academic Medical Center. 2002 C. Ronald Kahn, M.D. Lessons about the Control of Glucose Homeostasis and the Pathogenesis of Diabetes from Knockout Mice. 2003 Ronald G. Crystal, M.D. Therapy for the New Millennium: Using Genetic Medicine to Regenerate Diseased Organs and Protect Against the Hostile Environment. 2004 Victor A. McKusick, M.D. The Legacy of Jonathan Hutchinson (1828– 1913): Syndromology and Dysmorphology Meet Molecular Genetics. 2005 Charles A. Czeisler, M.D., Ph.D. Work Hours, Sleep and Patient Safety in Residency Training. 2006 Gerald W. Dorn, II, M.D. Neurohormonal Signaling Pathways That Link Cardiac Growth and Death. 2007 Abraham Verghese, M.D. “The Doctor in Our Own Time”: Fildes’ Famous Painting and Perceptions of Physician Attentiveness. 2008 Michael Welsh, M.D. Developing New Models to Understand Cystic Fibrosis 2009 Michael A. Gimbrone, Jr., M.D. Understanding Vascular Endothelium: A Pilgrim’s Progress 2010 Lawrence K. Altman, M.D. Who Goes First? Historical and Ethical Issues in Self-Experimentation 2011 Charles L. Sawyers, M.D. Overcoming Drug Resistance to New Cancer Therapies 2012 Andrew P. Feinberg, M.D., MPH. The Epigenetic Basis of Common Human Disease 2013 Peter C. Agre, M.D. Opening Doors Worldwide Through Medical Science, Personal Reflections 2014 Peter M. Howley, M.D. Infectious Disease Causes of Cancer: Opportunities for Prevention and Treatment 2015 Judy E. Garber, M.D., MPH. Evolution of Clinical Cancer Genetics 2016 Thomas McLellan, M.D. Substance Misuse and Substance Use Disorders: Why Do They Matter in Healthcare?

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THE GORDON WILSON LECTURES.

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