META-ANALYSIS e-ISSN 1643-3750 © Med Sci Monit, 2017; 23: 759-766 DOI: 10.12659/MSM.899905
The Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism Increases Myocardial Infarction Risk: A Meta-Analysis
Received: 2016.06.05 Accepted: 2016.07.05 Published: 2017.02.11
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
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Corresponding Author: Source of support:
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Xiang-Zhen Kong* Zheng-Yi Zhang* Lian-Hua Wei Rui Li Jing Yu
1 Department of Central Laboratory, Qinghai University Affiliated Hospital, Xining, Qinghai, P.R. China 2 Department of General Medicine, Lanzhou University Second Hospital, Lanzhou, Gansu, P.R. China 3 Department of Clinical Laboratory, People’s Hospital of Gansu Province, Lanzhou, Gansu, P.R. China 4 Stomatological Hospital of the Lanzhou University, Lanzhou, Gansu, P.R. China 5 Department of Hypertension, Lanzhou University Second Hospital, Lanzhou, Gansu, P.R. China
* These authors contributed equally to this work Jing Yu, e-mail: [email protected] This work was supported by Lanzhou City Science and Technology Development Projects Foundation: 2012-1-31
Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene are reportedly associated with myocardial infarction (MI) risk. However, definitive evidence of this association is lacking. In this study, we investigated the potential association of eNOS gene polymorphisms with MI risk by conducting a meta-analysis of studies evaluating this association. PubMed, Web of Knowledge, ScienceDirect, China National Knowledge Infrastructure (CNKI), WanFang, and Database of Chinese Scientific and Technical Periodicals (VIP) were searched for relevant studies. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to evaluate the association of eNOS gene T-786C and 4b4a polymorphisms with MI risk. Fifteen studies with 8,067 controls and 4,923 MI cases were included in the final meta-analysis. In the overall analysis, T-786C (rs2070744) polymorphism was associated with MI risk (p
The Endothelial Nitric Oxide Synthase Gene T-786C Polymorphism Increases Myocardial Infarction Risk: A Meta-Analysis
Received: 2016.06.05 Accepted: 2016.07.05 Published: 2017.02.11
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
BCDEF 1 BCDEF 2 EF 3 E 4 AEG 5
Corresponding Author: Source of support:
Background:
Material/Methods:
Results:
Conclusions:
MeSH Keywords:
Full-text PDF:
Xiang-Zhen Kong* Zheng-Yi Zhang* Lian-Hua Wei Rui Li Jing Yu
1 Department of Central Laboratory, Qinghai University Affiliated Hospital, Xining, Qinghai, P.R. China 2 Department of General Medicine, Lanzhou University Second Hospital, Lanzhou, Gansu, P.R. China 3 Department of Clinical Laboratory, People’s Hospital of Gansu Province, Lanzhou, Gansu, P.R. China 4 Stomatological Hospital of the Lanzhou University, Lanzhou, Gansu, P.R. China 5 Department of Hypertension, Lanzhou University Second Hospital, Lanzhou, Gansu, P.R. China
* These authors contributed equally to this work Jing Yu, e-mail: [email protected] This work was supported by Lanzhou City Science and Technology Development Projects Foundation: 2012-1-31
Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene are reportedly associated with myocardial infarction (MI) risk. However, definitive evidence of this association is lacking. In this study, we investigated the potential association of eNOS gene polymorphisms with MI risk by conducting a meta-analysis of studies evaluating this association. PubMed, Web of Knowledge, ScienceDirect, China National Knowledge Infrastructure (CNKI), WanFang, and Database of Chinese Scientific and Technical Periodicals (VIP) were searched for relevant studies. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to evaluate the association of eNOS gene T-786C and 4b4a polymorphisms with MI risk. Fifteen studies with 8,067 controls and 4,923 MI cases were included in the final meta-analysis. In the overall analysis, T-786C (rs2070744) polymorphism was associated with MI risk (p
