Accepted Manuscript The Elevated Level of ERα36 is correlated with Nodal Metastasis and Poor Prognosis in Lung Adenocarcinoma Shuming Zhang, Chen Qiu, Lei Wang, Qi Liu, Jiajun Du PII: DOI: Reference:

S0039-128X(14)00134-2 http://dx.doi.org/10.1016/j.steroids.2014.05.021 STE 7583

To appear in:

Steroids

Received Date: Revised Date: Accepted Date:

11 March 2014 18 May 2014 23 May 2014

Please cite this article as: Zhang, S., Qiu, C., Wang, L., Liu, Q., Du, J., The Elevated Level of ERα36 is correlated with Nodal Metastasis and Poor Prognosis in Lung Adenocarcinoma, Steroids (2014), doi: http://dx.doi.org/10.1016/ j.steroids.2014.05.021

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The Elevated Level of ERα36 is correlated with Nodal

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Metastasis and Poor Prognosis in Lung Adenocarcinoma

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*1 2 Shuming Zhang, *1Chen Qiu, 3Lei Wang ↑1 Qi Liu, ↑ 3Jiajun Du

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1. Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong

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University, Shandong University. 324 Jingwu Road, Jinan 250021, P.R. China.

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2. State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital,

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Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

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100871, P.R. China

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3. Department of Thoracic surgery, Shandong Provincial Hospital Affiliated to

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Shandong University, Shandong University. 324 Jingwu Road, Jinan 250021, P.R.

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China.

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* These authors equally contributed to this work.

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Email: [email protected], [email protected]

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Tel: +86-15964524862

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Fax: +86-0531-68777100

Corresponding author: Jiajun Du, Qi Liu

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Abstract

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Introduction: ERα36 is a recently cloned variant of estrogen receptor-alpha which

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has been proved to play an active role in a series of malignant diseases.

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Method: ERα36 expression was examined using immunohistochemical methods with

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sections from 126 resected NSCLC specimens. The immunoreactivity of ERα66 was

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also studied as a comparison. Kaplan-Meier method and multivariable Cox

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proportional hazards regression analyses were used to examine the relationship

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between ERα36 and survival.

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Result: ERα36 was more highly expressed in NSCLC patients compared to ERα66.

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ERα36 expression has a strong correlation with histology (AC: 53/70, SCC: 16/56,

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The elevated level of ERα36 is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma.

ERα36 is a recently cloned variant of estrogen receptor-alpha which has been proved to play an active role in a series of malignant diseases...
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