Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2015, Article ID 575898, 8 pages http://dx.doi.org/10.1155/2015/575898
Research Article The Efficacy of Endoscopic Papillary Balloon Dilation for Patients with Acute Biliary Pancreatitis Wei-Chih Sun,1 Hoi-Hung Chan,1,2,3,4 Kwok-Hung Lai,1,2 Tzung-Jiun Tsai,1 Huey-Shyan Lin,5 Kung-Hung Lin,1 Kai-Ming Wang,1 Sung-Shuo Kao,1,2 Po-Hung Chiang,1 Jin-Shiung Cheng,1,2 Ping-I Hsu,1,2 Wei-Lun Tsai,1,2 Wen-Chi Chen,1,2 Yun-Da Li,1 and E-Ming Wang1 1
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan School of Medicine, National Yang-Ming University, Taipei 112, Taiwan 3 Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan 5 Department of Health-Business Administration, Fooyin University, Kaohsiung 831, Taiwan 2
Correspondence should be addressed to Hoi-Hung Chan; [email protected] Received 31 October 2014; Revised 22 March 2015; Accepted 29 March 2015 Academic Editor: Vikram Kate Copyright © 2015 Wei-Chih Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. No study investigated the efficacy and safety of endoscopic papillary balloon dilation (EPBD) for the treatment of acute biliary pancreatitis (ABP). Method. We retrospectively reviewed the effects of EPBD on patients with ABP from February 2003 to December 2012. The general data, findings of image studies, details of the procedure, and outcomes after EPBD were analyzed. Result. Total 183 patients (male/female: 110/73) were enrolled. The mean age was 65.9 years. Among them, 155 patients had mild pancreatitis. The meantime from admission to EPBD was 3.3 days. Cholangiogram revealed filling defects inside the common bile duct (CBD) in 149 patients. The mean dilating balloon size was 10.5 mm and mean duration of the dilating procedure was 4.3 minutes. Overall, 124 patients had gross stones retrieved from CBD. Four (2.2%) adverse events and 2 (1.1%) intraprocedure bleeding incidents but no procedure-related mortality were noted. Bilirubin and amylase levels significantly decreased after EPBD. On average, patients resumed oral intake within 1.4 days. The clinical parameters and outcomes were similar in patients with different severity of pancreatitis. Conclusion. EPBD can be effective and safe for the treatment of ABP, even in patients presenting with severe disease.
1. Introduction Acute biliary pancreatitis (ABP) is a common disease with an annual incidence of 4.9–80.0/100,000 [1]. In the United States and Western Europe, 35–60% of the patients with acute pancreatitis resulted from biliary stone [2–4]. Although most of the cases with ABP are mild and self-limited, there are 20% of patients develop severe complications such as necrotizing pancreatitis and/or multiple organ failure with a mortality rate of 13–50% [2–5]. The pathogenesis of ABP is complex, and the main factor is transient or persistent ampullary obstruction by gallstones [6–9]. Prolonged obstruction will
aggravate pancreatic inflammation and contribute to severe pancreatitis [8]. Previous animal and human studies suggested that duration of obstruction over 48 hours may probably result in pancreatic necrosis [10–13]. With regard to this point of view, any measure that can relieve ampullary obstruction as soon as possible is a crucial part in minimizing the subsequent local or systemic complications [14]. Surgical removal of bile duct stones has been first advocated in 1978; however, the associated mortality was unacceptably high and up to 67% in a randomized trial [15, 16]. Sphincterotomy (EST) for the treatment of ABP was reported by Safrany et al. in 1980, with regard to its nature of less
2 invasiveness than that of surgery [17]. Current guidelines recommend emergency EST in the treatment of patients with ABP with concomitant cholangitis and/or persistent biliary obstruction regardless of the predicted severity of pancreatitis [18–21]. On the other hand, endoscopic papillary balloon dilation (EPBD), which is easy to perform using the wireguided method, has become an alternative to EST for the treatment of CBDS since its first introduction by Staritz et al. in 1982 [22]. Although EPBD is not commonly used in western countries due to the consideration of post-ERCP pancreatitis, it is widely used as EST in Asian countries with good efficacy [23]. Nevertheless, no study assessed the effects of EPBD in patients with ABP. In order to investigate the efficacy and safety of EPBD in the treatment of ABP, we conducted a retrospective study to share the experience in our hospital.
2. Materials and Methods 2.1. Patients. Between February 2003 and December 2012, consecutive patients with ABP successfully managed by ERCP/EPBD in Kaohsiung Veterans General Hospital were reviewed. The successful EPBD was defined as a complete performance of balloon dilation and the subsequent stone extraction procedures with clearance of bile duct (no gross stone was found in cholangiography) within two endoscopic sessions. Total 500 patients were diagnosed of acute biliary pancreatitis. Among them, three hundred and seventeen patients who did not receive EPBD were excluded from the study, which include 25 contraindications with/without emergency percutaneous drainage, 30 refusals of ERCP, 96 cases of spontaneous stone pass-out before ERCP, 24 failures of ERCP, 93 cases of diagnostic ERCP only, 48 cases of EST, and one failure of EPBD. Diagnosis of acute pancreatitis was established when fulfilling any two of the following three criteria: (1) typical abdominal pain (acute onset of a persistent, severe, epigastric pain often radiating to back); (2) serum amylase or lipase levels higher than three times the upper limit of normal; (3) characteristic findings of acute pancreatitis in abdominal ultrasound or contrast-enhanced computed tomography (CECT) [18, 19, 24, 25]. A biliary etiology was based on the exclusion of alcoholic or metabolic causes of pancreatitis and the presence of at least one of the following criteria: (1) gallbladder stone or sludge found by ultrasound or CECT; (2) dilated common bile duct (CBD) found by ultrasound or CECT (diameter > 7 mm if gallbladder is intact and diameter > 11 mm if gallbladder has been removed); (3) abnormal liver biochemistries including alanine aminotransferase (ALT) > 40 U/L, alkaline phosphatase (Alk-P) > 128 U/L, 𝛾-glutamyltransferase (𝛾GT) > 60 U/L, or an elevated serum bilirubin level >1.6 mg/ dL. Severe pancreatitis was defined as Ranson’s score ≧ 3 and/or CT severity index > 3 [26, 27]. In addition, acute cholangitis was defined by Charcot’s triad (fever > 38.5∘ C, epigastric pain, and jaundice) or signs of sepsis [14]. Some meta-analyses did not suggest emergency ERCP for mild pancreatitis [28–30], so patients were stratified into group A (mild pancreatitis) and group B (severe pancreatitis) for further comparison of clinical outcomes and to determine which one was beneficial to the endoscopic procedure.
Gastroenterology Research and Practice 2.2. Timing of Endoscopic Treatment. Currently, all guidelines recommended an emergency ERCP in patients with ABP with coexisting cholangitis and/or persistent biliary obstruction, but the optimal timing for ERCP differed among the guidelines: within 72 hours after onset of symptoms (World Congress of Gastroenterology, American Thoracic Society, British Society of Gastroenterology, Dutch Society of Internal Medicine), within 24 hours after hospital admission (German and American College of Gastroenterology), or controversial (International Association of Pancreatology, American Gastroenterological Association, Japanese Guidelines) [31]. In our study, when patients had either concomitant cholangitis or persistent biliary obstruction with the presentation of Charcot’s triad, bacteremia, progressive abdominal pain, or deterioration of liver biochemistries, we tended to perform ERCP as early (within 72 hours after hospital admission) as possible. 2.3. Endoscopic Procedures. Patients were conscious for this procedure and received 10% xylocaine spray for local anesthesia of the pharynx, intramuscular injection with 40 mg hyoscine-N-butylbromide, and intramuscular injection with 25–50 mg meperidine. ERCP was performed in the standard manner using a side-view endoscope (JF-240; Olympus Optical Corporation, Tokyo, Japan). After selective cannulation of the common bile duct by the catheter, cholangiography was performed to evaluate the size of CBD, presence of filling defects inside CBD, and size of CBD filling defects. A 0.035-inch guide wire (Boston Scientific, Corp, MA, USA) was then inserted into the bile duct through the catheter. A dilating balloon (CRE balloon 5.5 cm in length, 6–8 mm/8– 10 mm/10–12 mm/12–15 mm in diameter; Boston Scientific, Corp, Ireland) was passed via the prepositioned 0.035inch guide wire into the bile duct. Using fluoroscopic and endoscopic guidance, the balloon was inflated with sterile saline solution up to the optimal size (at least > six mm in diameter) and duration (from 1.5 to 5 minutes) according to the patients’ condition and tolerance. In order to minimize the risk of perforation, the size of the balloon should be not exceed the size of the CBD. After the balloon and guide wire were removed, the CBDS was retrieved out using a Dormia basket or balloon-tipped catheter with or without the aid of mechanical lithotripsy (BML-4Q; Olympus Optical, Tokyo, Japan). Unnecessary cannulation or contrast injection of pancreatic duct was avoided. A second attempt of stone extraction was performed within three days if there was incomplete removal of stones in the first treatment session. All the patients were observed in the hospital for at least 24 hours after endoscopic treatment. 2.4. Assessments and Outcomes. Demographic data of patients and hospital course was collected from clinical records, including presence of juxtapapillary diverticula (JPD), pancreatic duct enhancement, CBD diameter, number and size of stones, size of dilating balloon, and dilating duration, and presence of extracted stone was recorded. Successful bile duct clearance was defined as complete if the final cholangiogram revealed no more filling defects. The day after the endoscopic
Gastroenterology Research and Practice procedure, a blood sample for measurement of serum amylase and total bilirubin was obtained. ERCP/EPBD related adverse events were recorded according to the definitions and grading systems from the consensus of an American Society of Gastrointestinal Endoscopy Workshop [32]. The definition for exacerbation of pancreatitis after ERCP is as follows: (1) new or worsened abdominal pain, (2) rise of serum amylase at least three times above the upper limit of normal at 24 hours after ERCP, (3) requiring at least 2 days of hospitalization (2-3 days: mild degree; 4–10 days: moderate degree; more than 10 days: severe degree). The definition for post-ERCP cholangitis is (1) fever > 38.5∘ C and (2) persistent cholestasis more than 24 hours. The definition for post-ERCP cholecystitis is (1) newly developed pain and tenderness in RUQ and (2) image of gallbladder wall thickening and pericholecystic fluid. The definition for post-ERCP bleeding is hematemesis and/or melena with a hemoglobin decrease of at least 2 g/dL or the need for blood transfusion. Time from admission to ERCP/EPBD, time to resume oral intake after ERCP/EPBD, total hospital days, incidence of ERCP/EPBD related adverse events, and evolutions of laboratory data were assessed to measure the clinical effect and safety of ERCP/EPBD on patients with ABP. 2.5. Ethics Statement. This study was approved by the Ethics Committee and the Institutional Review Board of the Kaohsiung Veterans General Hospital (VGHKS13-CT6-12). This is a retrospective study that did not involve patient intervention or the need for obtaining clinical specimens, and all the data were analyzed anonymously. Therefore, informed consent was waived. The waiving of informed consent was approved by the Kaohsiung Veterans General Hospital Institutional Review Board. 2.6. Statistical Analysis. All statistical analyses were performed using the PASW statistics (IBM, New York, NY, USA). The continuous valuables are expressed as mean ± SD. Pearson Chi-square analysis or Fisher’s exact test was used for the comparison of categorical variables, while continuous variables were compared using the paired-sample and independent-sample 𝑡-tests. Multivariable logistic regression was used to find out the possible predictors for CBD stones. A two-tailed 𝑃 value of 1.5 cm) (2 of them received mechanical lithotripsy in first session), whom required second endoscopic treatment to remove residual CBD stones within three days. The rate of positive pancreatic duct injection was 50.8% of patients, and it was significantly higher in the patients with severe pancreatitis than in those with mild pancreatitis (67.9% versus 47.7%, 𝑃 = 0.05). There were 5 (2.7%) procedure-related adverse events, including 3 mild pancreatitis, 1 cholangitis, and 1 cholecystitis. All the complications could be controlled by conservative treatment and no procedural mortality was noted. EPBD caused the reduction of serum amylase in 90.7% of patients and reduction of serum total bilirubin in 83.1% of patients. On average, time to resume oral intake after ERCP was 1.4 days. The average hospital day was 9.1 and 9.6 for patients with mild and severe pancreatitis, respectively. Patients were divided into two groups: (A) 155 patients with mild pancreatitis and (B) 28 patients with severe pancreatitis. Baseline data of the two groups of patients were shown in Table 1. Significant differences in serum level of WBC, blood sugar, amylase, and borderline significant differences in age and serum total bilirubin level were found between the two groups. There were significant difference in size of dilating balloon and borderline difference in pancreatic duct enhancement (Table 2). Other clinical outcomes were similar between the two groups. The evolution of serum total bilirubin and serum amylase level by EPBD in overall patients and between patients with the mild and severe degree of acute biliary pancreatitis was shown in Table 3. Between the two groups, the levels of serum total bilirubin were significantly different before EPBD but there was no significant difference after EPBD. The levels of serum total bilirubin were significantly decreased in overall patients, regardless of the severity of pancreatitis. Although the levels of serum amylase were significantly decreased after EPBD in overall patients, there were no such similar differences in the reduction of serum amylase between the two groups. Moreover, the levels of serum amylase before and after EPBD were not significantly different between the two groups. Multivariable logistic regression analysis revealed that old age and high serum bilirubin level before ERCP are significant predictors for gross stone retrieved during the ERCP/EPBD procedures (Table 3).
4. Discussion Since the introduction of endoscopic treatment of ABP, it has been proved to be beneficial to the outcome of the disease [33]. Although EPBD has been shown to be an alternative to EST to remove the common bile duct stones with a similar success rate and lower risk of immediate complications such as bleeding or perforation [32–38], the clinical effect of EPBD for the treatment of ABP is rarely reported due to the fact that
4
Gastroenterology Research and Practice
Table 1: Characteristics of overall patients and comparisons between patients with mild (A) and severe (B) degree of acute biliary pancreatitis. Characteristics Gender (male/female) Age (mean ± SD, years) Body mass index Symptom Fever Nausea and vomiting Abdominal pain Jaundice Laboratory data WBC (×103 cu mm−1 ) Platelet (×103 cu mm−1 ) INR AST/ALT (IU/L) Alk-P/𝛾-GT (IU/L) Total bilirubin (mg/dL) LDH (IU/L) Blood sugar (mg/dL) Amylase (IU/L) Lipase (IU/L) Radiological finding Gallbladder in situ Gallbladder stone Dilated CBD CBD stone
Overall (𝑛 = 183) 110/73 65.9 ± 17.5 24.7 ± 3.6
Group A (𝑛 = 155) 93/62 66.9 ± 17.3 24.7 ± 3.5
Group B (𝑛 = 28) 17/11 60.3 ± 17.6 24.9 ± 3.9
𝑃 value 0.94 0.06 0.71
44 111 103 145
34 94 85 119
10 17 18 26
0.09 0.99 0.35 0.12
11.7 ± 4.4 196 ± 66 1.04 ± 0.13 264 ± 443/275 ± 295 200 ± 142/479 ± 418 3.7 ± 2.7 311 ± 177 159 ± 67 1351 ± 1309 12310 ± 13871
11.3 ± 4.4 192 ± 67 1.06 ± 0.14 262 ± 477/261 ± 304 200 ± 145/459 ± 398 3.8 ± 2.8 303 ± 179 154 ± 62 1176 ± 1188 11419 ± 13535
13.6 ± 3.9 217 ± 58 1.04 ± 0.11 273 ± 170/351 ± 229 200 ± 126/595 ± 519 3.2 ± 1.5 349 ± 164 190 ± 84 2302 ± 1539 16798 ± 14918
0.01 0.09 0.37 0.84/0.14 0.99/0.25 0.09 0.23 0.04
Research Article The Efficacy of Endoscopic Papillary Balloon Dilation for Patients with Acute Biliary Pancreatitis Wei-Chih Sun,1 Hoi-Hung Chan,1,2,3,4 Kwok-Hung Lai,1,2 Tzung-Jiun Tsai,1 Huey-Shyan Lin,5 Kung-Hung Lin,1 Kai-Ming Wang,1 Sung-Shuo Kao,1,2 Po-Hung Chiang,1 Jin-Shiung Cheng,1,2 Ping-I Hsu,1,2 Wei-Lun Tsai,1,2 Wen-Chi Chen,1,2 Yun-Da Li,1 and E-Ming Wang1 1
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan School of Medicine, National Yang-Ming University, Taipei 112, Taiwan 3 Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan 5 Department of Health-Business Administration, Fooyin University, Kaohsiung 831, Taiwan 2
Correspondence should be addressed to Hoi-Hung Chan; [email protected] Received 31 October 2014; Revised 22 March 2015; Accepted 29 March 2015 Academic Editor: Vikram Kate Copyright © 2015 Wei-Chih Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. No study investigated the efficacy and safety of endoscopic papillary balloon dilation (EPBD) for the treatment of acute biliary pancreatitis (ABP). Method. We retrospectively reviewed the effects of EPBD on patients with ABP from February 2003 to December 2012. The general data, findings of image studies, details of the procedure, and outcomes after EPBD were analyzed. Result. Total 183 patients (male/female: 110/73) were enrolled. The mean age was 65.9 years. Among them, 155 patients had mild pancreatitis. The meantime from admission to EPBD was 3.3 days. Cholangiogram revealed filling defects inside the common bile duct (CBD) in 149 patients. The mean dilating balloon size was 10.5 mm and mean duration of the dilating procedure was 4.3 minutes. Overall, 124 patients had gross stones retrieved from CBD. Four (2.2%) adverse events and 2 (1.1%) intraprocedure bleeding incidents but no procedure-related mortality were noted. Bilirubin and amylase levels significantly decreased after EPBD. On average, patients resumed oral intake within 1.4 days. The clinical parameters and outcomes were similar in patients with different severity of pancreatitis. Conclusion. EPBD can be effective and safe for the treatment of ABP, even in patients presenting with severe disease.
1. Introduction Acute biliary pancreatitis (ABP) is a common disease with an annual incidence of 4.9–80.0/100,000 [1]. In the United States and Western Europe, 35–60% of the patients with acute pancreatitis resulted from biliary stone [2–4]. Although most of the cases with ABP are mild and self-limited, there are 20% of patients develop severe complications such as necrotizing pancreatitis and/or multiple organ failure with a mortality rate of 13–50% [2–5]. The pathogenesis of ABP is complex, and the main factor is transient or persistent ampullary obstruction by gallstones [6–9]. Prolonged obstruction will
aggravate pancreatic inflammation and contribute to severe pancreatitis [8]. Previous animal and human studies suggested that duration of obstruction over 48 hours may probably result in pancreatic necrosis [10–13]. With regard to this point of view, any measure that can relieve ampullary obstruction as soon as possible is a crucial part in minimizing the subsequent local or systemic complications [14]. Surgical removal of bile duct stones has been first advocated in 1978; however, the associated mortality was unacceptably high and up to 67% in a randomized trial [15, 16]. Sphincterotomy (EST) for the treatment of ABP was reported by Safrany et al. in 1980, with regard to its nature of less
2 invasiveness than that of surgery [17]. Current guidelines recommend emergency EST in the treatment of patients with ABP with concomitant cholangitis and/or persistent biliary obstruction regardless of the predicted severity of pancreatitis [18–21]. On the other hand, endoscopic papillary balloon dilation (EPBD), which is easy to perform using the wireguided method, has become an alternative to EST for the treatment of CBDS since its first introduction by Staritz et al. in 1982 [22]. Although EPBD is not commonly used in western countries due to the consideration of post-ERCP pancreatitis, it is widely used as EST in Asian countries with good efficacy [23]. Nevertheless, no study assessed the effects of EPBD in patients with ABP. In order to investigate the efficacy and safety of EPBD in the treatment of ABP, we conducted a retrospective study to share the experience in our hospital.
2. Materials and Methods 2.1. Patients. Between February 2003 and December 2012, consecutive patients with ABP successfully managed by ERCP/EPBD in Kaohsiung Veterans General Hospital were reviewed. The successful EPBD was defined as a complete performance of balloon dilation and the subsequent stone extraction procedures with clearance of bile duct (no gross stone was found in cholangiography) within two endoscopic sessions. Total 500 patients were diagnosed of acute biliary pancreatitis. Among them, three hundred and seventeen patients who did not receive EPBD were excluded from the study, which include 25 contraindications with/without emergency percutaneous drainage, 30 refusals of ERCP, 96 cases of spontaneous stone pass-out before ERCP, 24 failures of ERCP, 93 cases of diagnostic ERCP only, 48 cases of EST, and one failure of EPBD. Diagnosis of acute pancreatitis was established when fulfilling any two of the following three criteria: (1) typical abdominal pain (acute onset of a persistent, severe, epigastric pain often radiating to back); (2) serum amylase or lipase levels higher than three times the upper limit of normal; (3) characteristic findings of acute pancreatitis in abdominal ultrasound or contrast-enhanced computed tomography (CECT) [18, 19, 24, 25]. A biliary etiology was based on the exclusion of alcoholic or metabolic causes of pancreatitis and the presence of at least one of the following criteria: (1) gallbladder stone or sludge found by ultrasound or CECT; (2) dilated common bile duct (CBD) found by ultrasound or CECT (diameter > 7 mm if gallbladder is intact and diameter > 11 mm if gallbladder has been removed); (3) abnormal liver biochemistries including alanine aminotransferase (ALT) > 40 U/L, alkaline phosphatase (Alk-P) > 128 U/L, 𝛾-glutamyltransferase (𝛾GT) > 60 U/L, or an elevated serum bilirubin level >1.6 mg/ dL. Severe pancreatitis was defined as Ranson’s score ≧ 3 and/or CT severity index > 3 [26, 27]. In addition, acute cholangitis was defined by Charcot’s triad (fever > 38.5∘ C, epigastric pain, and jaundice) or signs of sepsis [14]. Some meta-analyses did not suggest emergency ERCP for mild pancreatitis [28–30], so patients were stratified into group A (mild pancreatitis) and group B (severe pancreatitis) for further comparison of clinical outcomes and to determine which one was beneficial to the endoscopic procedure.
Gastroenterology Research and Practice 2.2. Timing of Endoscopic Treatment. Currently, all guidelines recommended an emergency ERCP in patients with ABP with coexisting cholangitis and/or persistent biliary obstruction, but the optimal timing for ERCP differed among the guidelines: within 72 hours after onset of symptoms (World Congress of Gastroenterology, American Thoracic Society, British Society of Gastroenterology, Dutch Society of Internal Medicine), within 24 hours after hospital admission (German and American College of Gastroenterology), or controversial (International Association of Pancreatology, American Gastroenterological Association, Japanese Guidelines) [31]. In our study, when patients had either concomitant cholangitis or persistent biliary obstruction with the presentation of Charcot’s triad, bacteremia, progressive abdominal pain, or deterioration of liver biochemistries, we tended to perform ERCP as early (within 72 hours after hospital admission) as possible. 2.3. Endoscopic Procedures. Patients were conscious for this procedure and received 10% xylocaine spray for local anesthesia of the pharynx, intramuscular injection with 40 mg hyoscine-N-butylbromide, and intramuscular injection with 25–50 mg meperidine. ERCP was performed in the standard manner using a side-view endoscope (JF-240; Olympus Optical Corporation, Tokyo, Japan). After selective cannulation of the common bile duct by the catheter, cholangiography was performed to evaluate the size of CBD, presence of filling defects inside CBD, and size of CBD filling defects. A 0.035-inch guide wire (Boston Scientific, Corp, MA, USA) was then inserted into the bile duct through the catheter. A dilating balloon (CRE balloon 5.5 cm in length, 6–8 mm/8– 10 mm/10–12 mm/12–15 mm in diameter; Boston Scientific, Corp, Ireland) was passed via the prepositioned 0.035inch guide wire into the bile duct. Using fluoroscopic and endoscopic guidance, the balloon was inflated with sterile saline solution up to the optimal size (at least > six mm in diameter) and duration (from 1.5 to 5 minutes) according to the patients’ condition and tolerance. In order to minimize the risk of perforation, the size of the balloon should be not exceed the size of the CBD. After the balloon and guide wire were removed, the CBDS was retrieved out using a Dormia basket or balloon-tipped catheter with or without the aid of mechanical lithotripsy (BML-4Q; Olympus Optical, Tokyo, Japan). Unnecessary cannulation or contrast injection of pancreatic duct was avoided. A second attempt of stone extraction was performed within three days if there was incomplete removal of stones in the first treatment session. All the patients were observed in the hospital for at least 24 hours after endoscopic treatment. 2.4. Assessments and Outcomes. Demographic data of patients and hospital course was collected from clinical records, including presence of juxtapapillary diverticula (JPD), pancreatic duct enhancement, CBD diameter, number and size of stones, size of dilating balloon, and dilating duration, and presence of extracted stone was recorded. Successful bile duct clearance was defined as complete if the final cholangiogram revealed no more filling defects. The day after the endoscopic
Gastroenterology Research and Practice procedure, a blood sample for measurement of serum amylase and total bilirubin was obtained. ERCP/EPBD related adverse events were recorded according to the definitions and grading systems from the consensus of an American Society of Gastrointestinal Endoscopy Workshop [32]. The definition for exacerbation of pancreatitis after ERCP is as follows: (1) new or worsened abdominal pain, (2) rise of serum amylase at least three times above the upper limit of normal at 24 hours after ERCP, (3) requiring at least 2 days of hospitalization (2-3 days: mild degree; 4–10 days: moderate degree; more than 10 days: severe degree). The definition for post-ERCP cholangitis is (1) fever > 38.5∘ C and (2) persistent cholestasis more than 24 hours. The definition for post-ERCP cholecystitis is (1) newly developed pain and tenderness in RUQ and (2) image of gallbladder wall thickening and pericholecystic fluid. The definition for post-ERCP bleeding is hematemesis and/or melena with a hemoglobin decrease of at least 2 g/dL or the need for blood transfusion. Time from admission to ERCP/EPBD, time to resume oral intake after ERCP/EPBD, total hospital days, incidence of ERCP/EPBD related adverse events, and evolutions of laboratory data were assessed to measure the clinical effect and safety of ERCP/EPBD on patients with ABP. 2.5. Ethics Statement. This study was approved by the Ethics Committee and the Institutional Review Board of the Kaohsiung Veterans General Hospital (VGHKS13-CT6-12). This is a retrospective study that did not involve patient intervention or the need for obtaining clinical specimens, and all the data were analyzed anonymously. Therefore, informed consent was waived. The waiving of informed consent was approved by the Kaohsiung Veterans General Hospital Institutional Review Board. 2.6. Statistical Analysis. All statistical analyses were performed using the PASW statistics (IBM, New York, NY, USA). The continuous valuables are expressed as mean ± SD. Pearson Chi-square analysis or Fisher’s exact test was used for the comparison of categorical variables, while continuous variables were compared using the paired-sample and independent-sample 𝑡-tests. Multivariable logistic regression was used to find out the possible predictors for CBD stones. A two-tailed 𝑃 value of 1.5 cm) (2 of them received mechanical lithotripsy in first session), whom required second endoscopic treatment to remove residual CBD stones within three days. The rate of positive pancreatic duct injection was 50.8% of patients, and it was significantly higher in the patients with severe pancreatitis than in those with mild pancreatitis (67.9% versus 47.7%, 𝑃 = 0.05). There were 5 (2.7%) procedure-related adverse events, including 3 mild pancreatitis, 1 cholangitis, and 1 cholecystitis. All the complications could be controlled by conservative treatment and no procedural mortality was noted. EPBD caused the reduction of serum amylase in 90.7% of patients and reduction of serum total bilirubin in 83.1% of patients. On average, time to resume oral intake after ERCP was 1.4 days. The average hospital day was 9.1 and 9.6 for patients with mild and severe pancreatitis, respectively. Patients were divided into two groups: (A) 155 patients with mild pancreatitis and (B) 28 patients with severe pancreatitis. Baseline data of the two groups of patients were shown in Table 1. Significant differences in serum level of WBC, blood sugar, amylase, and borderline significant differences in age and serum total bilirubin level were found between the two groups. There were significant difference in size of dilating balloon and borderline difference in pancreatic duct enhancement (Table 2). Other clinical outcomes were similar between the two groups. The evolution of serum total bilirubin and serum amylase level by EPBD in overall patients and between patients with the mild and severe degree of acute biliary pancreatitis was shown in Table 3. Between the two groups, the levels of serum total bilirubin were significantly different before EPBD but there was no significant difference after EPBD. The levels of serum total bilirubin were significantly decreased in overall patients, regardless of the severity of pancreatitis. Although the levels of serum amylase were significantly decreased after EPBD in overall patients, there were no such similar differences in the reduction of serum amylase between the two groups. Moreover, the levels of serum amylase before and after EPBD were not significantly different between the two groups. Multivariable logistic regression analysis revealed that old age and high serum bilirubin level before ERCP are significant predictors for gross stone retrieved during the ERCP/EPBD procedures (Table 3).
4. Discussion Since the introduction of endoscopic treatment of ABP, it has been proved to be beneficial to the outcome of the disease [33]. Although EPBD has been shown to be an alternative to EST to remove the common bile duct stones with a similar success rate and lower risk of immediate complications such as bleeding or perforation [32–38], the clinical effect of EPBD for the treatment of ABP is rarely reported due to the fact that
4
Gastroenterology Research and Practice
Table 1: Characteristics of overall patients and comparisons between patients with mild (A) and severe (B) degree of acute biliary pancreatitis. Characteristics Gender (male/female) Age (mean ± SD, years) Body mass index Symptom Fever Nausea and vomiting Abdominal pain Jaundice Laboratory data WBC (×103 cu mm−1 ) Platelet (×103 cu mm−1 ) INR AST/ALT (IU/L) Alk-P/𝛾-GT (IU/L) Total bilirubin (mg/dL) LDH (IU/L) Blood sugar (mg/dL) Amylase (IU/L) Lipase (IU/L) Radiological finding Gallbladder in situ Gallbladder stone Dilated CBD CBD stone
Overall (𝑛 = 183) 110/73 65.9 ± 17.5 24.7 ± 3.6
Group A (𝑛 = 155) 93/62 66.9 ± 17.3 24.7 ± 3.5
Group B (𝑛 = 28) 17/11 60.3 ± 17.6 24.9 ± 3.9
𝑃 value 0.94 0.06 0.71
44 111 103 145
34 94 85 119
10 17 18 26
0.09 0.99 0.35 0.12
11.7 ± 4.4 196 ± 66 1.04 ± 0.13 264 ± 443/275 ± 295 200 ± 142/479 ± 418 3.7 ± 2.7 311 ± 177 159 ± 67 1351 ± 1309 12310 ± 13871
11.3 ± 4.4 192 ± 67 1.06 ± 0.14 262 ± 477/261 ± 304 200 ± 145/459 ± 398 3.8 ± 2.8 303 ± 179 154 ± 62 1176 ± 1188 11419 ± 13535
13.6 ± 3.9 217 ± 58 1.04 ± 0.11 273 ± 170/351 ± 229 200 ± 126/595 ± 519 3.2 ± 1.5 349 ± 164 190 ± 84 2302 ± 1539 16798 ± 14918
0.01 0.09 0.37 0.84/0.14 0.99/0.25 0.09 0.23 0.04
