The Effect of Glucagon on Airway Resistance RICHARD WILLIAM
G
apparent to
a reduction
was
also shown
chiolar study
was
therefore
patients
in
to
parameters
both before ministration
from
evaluate
bronchospasm,
and after the randomized of glucagon, isoproterenol,
Since
ador
after also
Nine
Several nificant
investigators correlations
less
sistance
and
other
26
chronic
parameters. study
have between pulmonary
Stein
of
and
with
(FEy1), (2fEF),
1-second
associates,8
ing
vital
airway
flow
a lesser
extent,
obstruction,
correlation
of
rate rate peak
and cosufferfound
specific
the
conductance
forced
with FEy1, Mi1IEF, MEF, and expiratory vital capacity (PVC).
Payne
and
(RGaw)
associates5
significant
correlations
and
with
gas
MEF
volume
the (V)
were
able
to
of PEV, product and
of Raw
show
Medical 680
Center of
College, New
for Norwalk, Medicine,
York,
Respiratory Conn. Cornell
N.Y.
75
the
sex,
cent
and
ard, the
Waltham, testing
daily with
apart.
performed.
This
in
COLD
Research, 06856, and University
10021.
MEF
were
est
values
for
taken
as the
washout
study
followed
again
The
recorded. two
was
Journal
a was
by
maneuvers.
these
nebulizer
MEF
and minutes,
was
of the
subject began maneuvers
FEy1
baseline
Medication in-line
part
several
forced-expiration
and
three per-
respira-
The first established
After
MMEF,
patient on was
(Hewlett-Pack-
Mass.). procedure
thoracic
of
each
VR-6100
computer
nitrogen
more
for
per day testing
a Vertek
minutes
patients
characteristics
All
recorded.
the
clinical bronI shows the
baseline values. The two forced-expiration
several were
for
function
stable Table
physical
with
values selected
while
studied. procedure days.
function
drugs
obstructive
pulmonary
1#{189} hours
tory
were
the
were
performed
to
formed
tests
in ventila-
clinical
The
patients The entire
took up consecutive
washout
FEV1/FVC’%
per
steady-state
patients. From the Hinds Norwalk Hospital, the Department
with and
study.
age,
in-
Methods
subjects
were
pafrom
of
were in a relatively choconstrictive state.
capacity flow
flow (PEP). Mitchell in a study of 39 patients
from
best
to
a dis-
airway corre-
midexpiratory
and,
(2IIMEF),
expiratory workers,4
showed
expiratory
maximal
this
these
changes
administration be followed.
than
N.Y.
is correlated
bronchospasm
Nitrogen
disease
studies
in lung
inversely
forced
maximal
sigre-
function
obstructive
ease (COLD) patients, resistance (Rap0) to be lated
shown airway
in
and
York,
to collectively
so that
Materials
Sc.B.,
New
PEF,
and
followed
levels.
tion might
and
conductance
changes performed
MAGUIRE.
Conn.,
JIEF,
were
also
saline.
isotonic
airway
dicate
airway
WILLIAM
Norwalk,
FE V1.
control
This
designed
M.D..
M.D.
rameters
bron-
vitro.2
function
suffering
NAIR.
with It
pig
GOLDFEDDER.
an
canine
vivo, leading
guinea
muscle
pulmonary
have on
flow resistance.1
to relax
smooth
several of
air
in
ALAN
SREEDHAR
to
effect
muscle of
and
shown
relaxing smooth
Ph.D..
M.D..
been
has
LUCAGON
bronchial
IMBRUCE,
BRISCOE.
two FEy1
The
parameters
highwere
values. then
of
delivered
a PR-i of
Clinical
from
positive-presPharmacology
an
GLUCAGON
ON
AiRWAY
RESISTANCE
TABLE Age,
Sex,
I
Physical
and
Characteristics
Patient
Height
no.
Age
(yrs)
female male female female female male
respiratory
random days
protocol. of study,
saline,
each
unit
(Puritan-
On the
each patient
isoproterenol,
procedure.
or
values for The hospital
a coded
vial The
drugs were given patient. Glueagon
of
was
in vivo study glucagon.1 1/200,
order
isotonic After jects tions.
was
total
taken value. washout
30 cent
by
to 2.0 consisted
(Isuprelf)
II
days
for
values
cc. cc
rest
period,
as
the
the
forced the
expirahighest
10-minutes-after-
This was followed study, which in two
more
after over
sub-
forced
by a turn
expira-
medication.
The
baseline
values
Indianapolis,
md.
for
Eli Lilly & Company,
tWinthrop
October,
Laboratories, 1975
New
York,
N.Y.
patient.
All
Figures cent change
1 and from
2 show baseline
and
at
MEF
values
were
minutes
both
10
the
cent. the values and
mean per of FEV1
30
minutes.
mean
significantly
increased and
while
three
FEV1/FVC%
isoproterenol, (P
G
apparent to
a reduction
was
also shown
chiolar study
was
therefore
patients
in
to
parameters
both before ministration
from
evaluate
bronchospasm,
and after the randomized of glucagon, isoproterenol,
Since
ador
after also
Nine
Several nificant
investigators correlations
less
sistance
and
other
26
chronic
parameters. study
have between pulmonary
Stein
of
and
with
(FEy1), (2fEF),
1-second
associates,8
ing
vital
airway
flow
a lesser
extent,
obstruction,
correlation
of
rate rate peak
and cosufferfound
specific
the
conductance
forced
with FEy1, Mi1IEF, MEF, and expiratory vital capacity (PVC).
Payne
and
(RGaw)
associates5
significant
correlations
and
with
gas
MEF
volume
the (V)
were
able
to
of PEV, product and
of Raw
show
Medical 680
Center of
College, New
for Norwalk, Medicine,
York,
Respiratory Conn. Cornell
N.Y.
75
the
sex,
cent
and
ard, the
Waltham, testing
daily with
apart.
performed.
This
in
COLD
Research, 06856, and University
10021.
MEF
were
est
values
for
taken
as the
washout
study
followed
again
The
recorded. two
was
Journal
a was
by
maneuvers.
these
nebulizer
MEF
and minutes,
was
of the
subject began maneuvers
FEy1
baseline
Medication in-line
part
several
forced-expiration
and
three per-
respira-
The first established
After
MMEF,
patient on was
(Hewlett-Pack-
Mass.). procedure
thoracic
of
each
VR-6100
computer
nitrogen
more
for
per day testing
a Vertek
minutes
patients
characteristics
All
recorded.
the
clinical bronI shows the
baseline values. The two forced-expiration
several were
for
function
stable Table
physical
with
values selected
while
studied. procedure days.
function
drugs
obstructive
pulmonary
1#{189} hours
tory
were
the
were
performed
to
formed
tests
in ventila-
clinical
The
patients The entire
took up consecutive
washout
FEV1/FVC’%
per
steady-state
patients. From the Hinds Norwalk Hospital, the Department
with and
study.
age,
in-
Methods
subjects
were
pafrom
of
were in a relatively choconstrictive state.
capacity flow
flow (PEP). Mitchell in a study of 39 patients
from
best
to
a dis-
airway corre-
midexpiratory
and,
(2IIMEF),
expiratory workers,4
showed
expiratory
maximal
this
these
changes
administration be followed.
than
N.Y.
is correlated
bronchospasm
Nitrogen
disease
studies
in lung
inversely
forced
maximal
sigre-
function
obstructive
ease (COLD) patients, resistance (Rap0) to be lated
shown airway
in
and
York,
to collectively
so that
Materials
Sc.B.,
New
PEF,
and
followed
levels.
tion might
and
conductance
changes performed
MAGUIRE.
Conn.,
JIEF,
were
also
saline.
isotonic
airway
dicate
airway
WILLIAM
Norwalk,
FE V1.
control
This
designed
M.D..
M.D.
rameters
bron-
vitro.2
function
suffering
NAIR.
with It
pig
GOLDFEDDER.
an
canine
vivo, leading
guinea
muscle
pulmonary
have on
flow resistance.1
to relax
smooth
several of
air
in
ALAN
SREEDHAR
to
effect
muscle of
and
shown
relaxing smooth
Ph.D..
M.D..
been
has
LUCAGON
bronchial
IMBRUCE,
BRISCOE.
two FEy1
The
parameters
highwere
values. then
of
delivered
a PR-i of
Clinical
from
positive-presPharmacology
an
GLUCAGON
ON
AiRWAY
RESISTANCE
TABLE Age,
Sex,
I
Physical
and
Characteristics
Patient
Height
no.
Age
(yrs)
female male female female female male
respiratory
random days
protocol. of study,
saline,
each
unit
(Puritan-
On the
each patient
isoproterenol,
procedure.
or
values for The hospital
a coded
vial The
drugs were given patient. Glueagon
of
was
in vivo study glucagon.1 1/200,
order
isotonic After jects tions.
was
total
taken value. washout
30 cent
by
to 2.0 consisted
(Isuprelf)
II
days
for
values
cc. cc
rest
period,
as
the
the
forced the
expirahighest
10-minutes-after-
This was followed study, which in two
more
after over
sub-
forced
by a turn
expira-
medication.
The
baseline
values
Indianapolis,
md.
for
Eli Lilly & Company,
tWinthrop
October,
Laboratories, 1975
New
York,
N.Y.
patient.
All
Figures cent change
1 and from
2 show baseline
and
at
MEF
values
were
minutes
both
10
the
cent. the values and
mean per of FEV1
30
minutes.
mean
significantly
increased and
while
three
FEV1/FVC%
isoproterenol, (P
