The Japanese Journal of Psychiatry and Neurology, Vol. 46, No. 2, 1992

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Electroencephalogram and Clinical Neurophysiology The Effect of Anticonvulsants on EEG Background Activity in Epileptic Children with Monopharmacy Kazuhisa Hongou, M.D., Tohru Konishi, M.D., Yoshihiro Naganuma, M.D., Miyako Murakami, M.D., Miwa Yamatani, M.D. and Toshio Okada, M.D. Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama Introduction The development of the EEG background activity is frequently impaired in epileptic children. But it is difficult to evaluate the contribution of various factors to the EEG background activity. We studied the effects of antiepileptic drugs (AED) on the EEG background activity in epileptic children with monopharmacy. Subjects and Methods The subjects were 66 epileptic children with monopharmacy (CBZ; 39 cases and VPA; 21 cases). The EEG was recorded every 6 months in each patient from the onset (before administration of AED) to one year after discontinuation of AED. The mean ages at starting medication were 8.3f3.0 in the CBZ group and 11.3f2.9 in the VPA group, and those at the final seizure attack was 8.3k2.7 in the CBZ group and 11.0k3.4 in the VPA group, and those at discontinuation of AED was 11.5+2.5 in the CBZ group and 11.8f4.2 in the VPA group. The EEG was taken applying the 10-20 system of electrode placement. The bandpass filters were set at 60 Hz. The EEG was additionally recorded on magnetic tape. Out of 3 min of recording with eyes closed, the EEG sample for an analysis was chosen free of artifacts and

paroxysmal judged by inspection. The computerized spectral analysis was done by the record of 0 1 derivations, using Fast Fourier Transformation. Digital conversion was undertaken with 64 Hz. The record was divided into 16 epochs of an 8-sec duration. The spectral analysis resulted in 200 values within 0.5-25 Hz and calculated total power, mean frequency and relative powers in delta (0.5-3.85 Hz), theta (47.85 Hz), alphal (8-9.85 Hz), alpha2 (1012.85 Hz), beta1 (13-19.85 Hz), beat 2 (2025 Hz). The log(X) for both relative band power and total power were evaluated. The changes in the EEG background activity were compared between before and after starting administration of AED, between before and after discontinuation of AED, using the paired t-test. The changes from 6 to 30 months after the final seizure attack was analyzed by 2 way ANOVA in a patient who had not any seizures for at least 30 months. Results 1) As to the changes in the EEG between before and after starting AED. The relative power in delta decreased after starting VPA (p

The effect of anticonvulsants on EEG background activity in epileptic children with monopharmacy.

The Japanese Journal of Psychiatry and Neurology, Vol. 46, No. 2, 1992 475 Electroencephalogram and Clinical Neurophysiology The Effect of Anticonvu...
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