Clin Physiol Funct Imaging (2016) 36, pp218–224
doi: 10.1111/cpf.12216
The diagnostic performance of cardiac magnetic resonance in detection of myocardial involvement in AL amyloidosis Michal Fikrle1, Tomas Palecek1,2, Martin Masek3, Petr Kuchynka1,2, Jan Straub4, Ivan Spicka4, Romana Rysava5 and Ales Linhart1 1
2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, 2International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 3Department of Radiology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, 41st Department of Medicine, Department of Hematology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, and 5Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
Summary Correspondence Tomas Palecek, 2nd Department of Medicine, Department of Cardiovascular Medicine, General University Hospital in Prague, First Faculty of Medicine, Charles University in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic E-mail:[email protected]
Accepted for publication Received 24 January 2014; accepted 21 October 2014
Key words AL amyloidosis; cardiac magnetic resonance; cardiomyopathy; echocardiography; late gadolinium enhancement
Background The non-invasive assessment of amyloid heart disease may be challenging. Cardiac magnetic resonance (CMR) represents a method of choice for assessment of left ventricular (LV) morphology and function, and it also provides a unique possibility to evaluate the presence of amyloid deposition by the late gadolinium enhancement (LGE) technique. However, so far, published studies have not been consistent in terms of described LGE patterns associated with amyloid cardiomyopathy. Aims To compare echocardiographic and CMR assessment of LV morphology and function and to evaluate the presence and pattern of LGE in a population of patients with AL amyloid cardiomyopathy. Methods Twenty-two consecutive patients with newly diagnosed AL amyloid cardiomyopathy and without contraindications to CMR were comprehensively examined by echocardiography and CMR. Results Echocardiography and CMR did not differ in the evaluation of interventricular septal thickness, LV end-diastolic diameter and ejection fraction. Significant differences were found between echocardiographic and CMR estimates of LV enddiastolic volume (P
doi: 10.1111/cpf.12216
The diagnostic performance of cardiac magnetic resonance in detection of myocardial involvement in AL amyloidosis Michal Fikrle1, Tomas Palecek1,2, Martin Masek3, Petr Kuchynka1,2, Jan Straub4, Ivan Spicka4, Romana Rysava5 and Ales Linhart1 1
2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, 2International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, 3Department of Radiology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, 41st Department of Medicine, Department of Hematology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, and 5Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
Summary Correspondence Tomas Palecek, 2nd Department of Medicine, Department of Cardiovascular Medicine, General University Hospital in Prague, First Faculty of Medicine, Charles University in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic E-mail:[email protected]
Accepted for publication Received 24 January 2014; accepted 21 October 2014
Key words AL amyloidosis; cardiac magnetic resonance; cardiomyopathy; echocardiography; late gadolinium enhancement
Background The non-invasive assessment of amyloid heart disease may be challenging. Cardiac magnetic resonance (CMR) represents a method of choice for assessment of left ventricular (LV) morphology and function, and it also provides a unique possibility to evaluate the presence of amyloid deposition by the late gadolinium enhancement (LGE) technique. However, so far, published studies have not been consistent in terms of described LGE patterns associated with amyloid cardiomyopathy. Aims To compare echocardiographic and CMR assessment of LV morphology and function and to evaluate the presence and pattern of LGE in a population of patients with AL amyloid cardiomyopathy. Methods Twenty-two consecutive patients with newly diagnosed AL amyloid cardiomyopathy and without contraindications to CMR were comprehensively examined by echocardiography and CMR. Results Echocardiography and CMR did not differ in the evaluation of interventricular septal thickness, LV end-diastolic diameter and ejection fraction. Significant differences were found between echocardiographic and CMR estimates of LV enddiastolic volume (P
