Int J Hematol (2015) 101:527–535 DOI 10.1007/s12185-015-1787-z
REVIEW ARTICLE
The diagnosis and treatment of aplastic anemia: a review Maurizio Miano1 · Carlo Dufour1
Received: 10 November 2014 / Revised: 17 March 2015 / Accepted: 24 March 2015 / Published online: 3 April 2015 © The Japanese Society of Hematology 2015
Abstract Aplastic anemia is a rare disorder characterized by suppression of bone marrow function resulting in progressive pancytopenia. A trigger-related abnormal T cell response facilitated by some genetic predisposition has been postulated as the pathogenetic mechanism leading to the overproduction of bone marrow-inhibiting cytokines. Immuno-mediated pathogenesis is confirmed by the response to immunosuppressive treatment (IST) (cyclosporin A+ATG), which represents the first-choice therapy for patients
REVIEW ARTICLE
The diagnosis and treatment of aplastic anemia: a review Maurizio Miano1 · Carlo Dufour1
Received: 10 November 2014 / Revised: 17 March 2015 / Accepted: 24 March 2015 / Published online: 3 April 2015 © The Japanese Society of Hematology 2015
Abstract Aplastic anemia is a rare disorder characterized by suppression of bone marrow function resulting in progressive pancytopenia. A trigger-related abnormal T cell response facilitated by some genetic predisposition has been postulated as the pathogenetic mechanism leading to the overproduction of bone marrow-inhibiting cytokines. Immuno-mediated pathogenesis is confirmed by the response to immunosuppressive treatment (IST) (cyclosporin A+ATG), which represents the first-choice therapy for patients
