Cell, Vol. 64, 891-901,

March

8, 1991. Copyright

0 1991 by Cell Press

The Cytoplasmic Domain of the T Cell Receptor 6 Chain Is Sufficient to Couple to Receptor-Associated Signal Transduction Pathways Elryan A. Irving’ and Arthur Weisst tHoward Hughes Medical Institute Departments of Medicine, Microbiology Department of Physiology University of California, San Francisco San Francisco, California 94143

and Immunology

l

Summary The function of the T cell antigen receptor (TM) invariant chains, CD3 y, S, E, and

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways.

The function of the T cell antigen receptor (TCR) invariant chains, CD3 gamma, delta, epsilon, and zeta, is poorly understood. Evidence suggests that ...
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