Tumor Biol. DOI 10.1007/s13277-014-2072-0

RESEARCH ARTICLE

The ATP7B genetic polymorphisms predict clinical outcome to platinum-based chemotherapy in lung cancer patients Xiang-Ping Li & Ji-Ye Yin & Ying Wang & Hui He & Xi Li & Wei-Jing Gong & Juan Chen & Chen-Yue Qian & Yi Zheng & Fang Li & Tao Yin & Zhi-Cheng Gong & Bo-Ting Zhou & Yu Zhang & Ling Xiao & Hong-Hao Zhou & Zhao-Qian Liu

Received: 17 February 2014 / Accepted: 6 May 2014 # International Society of Oncology and BioMarkers (ISOBM) 2014

Abstract This study aims to investigate the influence of ATP7B genetic polymorphism to platinum-based chemotherapy in Chinese Han lung cancer patients. A total of 338 Chinese Han lung cancer patients were enrolled in this study. All patients underwent at least two cycles of platinum-based chemotherapy. Four tag SNPs of ATP7B (rs1061472, rs9535826, rs7999812, and rs9535828) were selected to evaluate their impacts to platinum-based chemotherapy in these patients. ATP7B rs9535828 and rs9535826 were found to be associated with platinum resistance in Chinese Han lung cancer patients. Patients with A allele in ATP7B rs9535828 presented an increased susceptibility to platinum drugs (OR 1.96, 95 % CI 1.17–3.30, p

The ATP7B genetic polymorphisms predict clinical outcome to platinum-based chemotherapy in lung cancer patients.

This study aims to investigate the influence of ATP7B genetic polymorphism to platinum-based chemotherapy in Chinese Han lung cancer patients. A total...
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