HHS Public Access Author manuscript Author Manuscript
Hypertension. Author manuscript; available in PMC 2017 July 01. Published in final edited form as: Hypertension. 2016 July ; 68(1): 39–45. doi:10.1161/HYPERTENSIONAHA.115.06960.
The Association between Antihypertensive Medication Nonadherence and Visit-to-Visit Variability of Blood Pressure: Findings from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Author Manuscript
Ian M. Kronish, MD, MPH1, Amy I. Lynch, PhD2, Suzanne Oparil, MD3, Jeff Whittle, MD, MPH4, Barry R. Davis, MD, PhD5, Lara M. Simpson, PhD5, Marie Krousel-Wood, MD, MSPH6,7,8, William C. Cushman, MD9, Tara I. Chang, MD, MS10, and Paul Muntner, PhD2 1Center
for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY
2Department
of Epidemiology, University of Alabama at Birmingham, Birmingham, AL
3Division
of Cardiology, University of Alabama at Birmingham, Birmingham, AL
4Primary
Care Division, Clement J. Zablocki VA Medical Center, Milwaukee, WI
5Coordinating
Center for Clinical Trials, The University of Texas School of Public Health, Houston,
TX
Author Manuscript
6Department
of Medicine, Tulane University School of Medicine
7Department
of Epidemiology, Tulane University School of Public Health
8Tropical
Medicine, Research Division, Ochsner Health System
9Preventive 10Division
Medicine Section, Veterans Affairs Medical Center, Memphis, TN
of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo
Alto, CA
Abstract
Author Manuscript
Low adherence to antihypertensive medication has been hypothesized to increase visit-to-visit variability (VVV) of blood pressure (BP). We assessed the association between antihypertensive medication adherence and VVV of BP in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). VVV of BP was calculated using standard deviation independent of the mean (SDIM), standard deviation, and average real variability across study visits conducted 6 to 28 months following randomization. Participants who reported taking
Hypertension. Author manuscript; available in PMC 2017 July 01. Published in final edited form as: Hypertension. 2016 July ; 68(1): 39–45. doi:10.1161/HYPERTENSIONAHA.115.06960.
The Association between Antihypertensive Medication Nonadherence and Visit-to-Visit Variability of Blood Pressure: Findings from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Author Manuscript
Ian M. Kronish, MD, MPH1, Amy I. Lynch, PhD2, Suzanne Oparil, MD3, Jeff Whittle, MD, MPH4, Barry R. Davis, MD, PhD5, Lara M. Simpson, PhD5, Marie Krousel-Wood, MD, MSPH6,7,8, William C. Cushman, MD9, Tara I. Chang, MD, MS10, and Paul Muntner, PhD2 1Center
for Behavioral Cardiovascular Health, Columbia University Medical Center, New York, NY
2Department
of Epidemiology, University of Alabama at Birmingham, Birmingham, AL
3Division
of Cardiology, University of Alabama at Birmingham, Birmingham, AL
4Primary
Care Division, Clement J. Zablocki VA Medical Center, Milwaukee, WI
5Coordinating
Center for Clinical Trials, The University of Texas School of Public Health, Houston,
TX
Author Manuscript
6Department
of Medicine, Tulane University School of Medicine
7Department
of Epidemiology, Tulane University School of Public Health
8Tropical
Medicine, Research Division, Ochsner Health System
9Preventive 10Division
Medicine Section, Veterans Affairs Medical Center, Memphis, TN
of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo
Alto, CA
Abstract
Author Manuscript
Low adherence to antihypertensive medication has been hypothesized to increase visit-to-visit variability (VVV) of blood pressure (BP). We assessed the association between antihypertensive medication adherence and VVV of BP in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). VVV of BP was calculated using standard deviation independent of the mean (SDIM), standard deviation, and average real variability across study visits conducted 6 to 28 months following randomization. Participants who reported taking
