American Journal of Epidemiology Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
Vol. 183, No. 2 DOI: 10.1093/aje/kwv170 Advance Access publication: December 15, 2015
Original Contribution The Association Between Alcohol Consumption and Lung Carcinoma by Histological Subtype
Jose Ramon Troche*, Susan T. Mayne, Neal D. Freedman, Fatma M. Shebl, and Christian C. Abnet * Correspondence to Jose Ramon Troche, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20892 (e-mail: [email protected]
Initially submitted February 20, 2015; accepted for publication June 22, 2015.
Alcohol is a carcinogen suspected of increasing lung cancer risk. Therefore, we prospectively evaluated the relationship between alcohol consumption and lung carcinoma in 492,902 persons from the National Institutes of Health-AARP Diet and Health Study. We used Cox models to calculate hazard ratios and 95% confidence intervals, adjusting for tobacco smoking and other potential confounders. Between 1995/1996 and December 31, 2006, there were 10,227 incident cases of lung carcinoma, classified as adenocarcinoma (n = 4,036), squamous cell carcinoma (n = 1,998), small cell carcinoma (n = 1,524), undifferentiated carcinoma (n = 559), and other (n = 2,110). Compared with nondrinking, alcohol consumption was associated with a modest nonlinear reduction in total lung carcinoma risk at lower levels of consumption (for 0.5–