www.impactjournals.com/oncotarget/

Oncotarget, 2016, Vol. 7, (No. 50), pp: 82972-82984 Research Paper

14-3-3ζ/TGFβR1 promotes tumor metastasis in lung squamous cell carcinoma Yanbin Zhao1,*, Wenbo Qiao2,*, Xiaoyuan Wang1,*, Hang Yin2, Jianqi Cui1, Yue Cui1, Xuesong Chen1, Jing Hu1, Hailing Lu1, Qingwei Meng1, Yan Wang1, Li Cai1 1

The Department of Internal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China

2

The Department of radiotherapy, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China

*

These three authors contributed equally to this work

Correspondence to: Li Cai, email: [email protected] Yan Wang, email: [email protected] Keywords: 14-3-3ζ, TGFβR1, metastasis, lung squamous cell carcinoma, EMT Received: June 06, 2016     Accepted: September 17, 2016     Published: October 15, 2016

ABSTRACT 14-3-3ζ is involved in tumor cell growth and apoptosis. However, the mechanism of 14-3-3ζ in lung squamous cell carcinoma (SCC) metastasis has not been illuminated. In our studies, we found that the expression of 14-3-3ζ was highly expressed in lung SCC compared to normal lung tissues. High expression of 14-3-3ζ was associated with pTNM stage (p