Histopathology 1992, 20, 427-431
Teratoid Wilms’ tumour: a report of two cases J.F.MAGEE, S.ANSARI*, D.E.McFADDEN & J.DIMMICK Department of Pathology, University of British Columbia and B.C. Children’s Hospital and *Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada Date of submission 1 3 May 1991 Accepted for publication 9 December 1991
MAGEE J . F . , ANSARI S . . MCFADDEN D.E. & DIMMICK J
(1992) Histopathology 20, 427-431
Teratoid Wilms’ tumour: a report of two cases We report two cases of Wilms’ tumour in which the degree of heterologous differentiation was sufficient to warrant the diagnosis of teratoid Wilms’ tumour. The first description of neural elements in this Wilms’ variant and the first cytogenetic analysis of teratoid Wilms’ tumour are presented. Keywords: Wilms’ tumour, teratoid variant, neural differentiation
Introduction Wilms’ tumour is the most common renal tumour of childhood’. It is an embryonal neoplasm that is generally assumed to arise from metanephric blastema. Typically, it exhibits a triphasic histological pattern of blastema, epithelium and stroma. Small foci of heterologous elements such as cartilage, bone or muscle are not infrequently present and, more rarely, neural elements have been described2-8. The term teratoid Wilms’ tumour was introduced by Variend et aL9 to define a variant of nephroblastoma in which the heterologous tissue predominated. To date, five tumours of this type have been documented in the literature, four of which have been bilateral9-’ The present report describes two further cases, both of which presented as stage I tumours. For the first time, neural elements are described in this variant, and cytogenetic analysis of a teratoid Wilms’ tumour is presented.
’.
Materials and methods Microscopic examination of each tumour was performed on formalin and Bouins-fixed, paraffin-embedded tissue. Both tumours were extensively sectioned for histological examination. Immunostaining was performed on 3 pm-thick sections cut from selected Bouins-fixed paraffin-embedded Address for correspondence: Dr J.F.Magee. Department of Anatomic and Surgical Pathology, British Columbia’s Children’s Hospital. 4480 Oak Street, Vancouver, British Columbia V6H 3V4. Canada.
blocks. An avidin-biotin technique was used for immunohistochemical stainingl2
Teratoid Wilms’ tumour: a report of two cases J.F.MAGEE, S.ANSARI*, D.E.McFADDEN & J.DIMMICK Department of Pathology, University of British Columbia and B.C. Children’s Hospital and *Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada Date of submission 1 3 May 1991 Accepted for publication 9 December 1991
MAGEE J . F . , ANSARI S . . MCFADDEN D.E. & DIMMICK J
(1992) Histopathology 20, 427-431
Teratoid Wilms’ tumour: a report of two cases We report two cases of Wilms’ tumour in which the degree of heterologous differentiation was sufficient to warrant the diagnosis of teratoid Wilms’ tumour. The first description of neural elements in this Wilms’ variant and the first cytogenetic analysis of teratoid Wilms’ tumour are presented. Keywords: Wilms’ tumour, teratoid variant, neural differentiation
Introduction Wilms’ tumour is the most common renal tumour of childhood’. It is an embryonal neoplasm that is generally assumed to arise from metanephric blastema. Typically, it exhibits a triphasic histological pattern of blastema, epithelium and stroma. Small foci of heterologous elements such as cartilage, bone or muscle are not infrequently present and, more rarely, neural elements have been described2-8. The term teratoid Wilms’ tumour was introduced by Variend et aL9 to define a variant of nephroblastoma in which the heterologous tissue predominated. To date, five tumours of this type have been documented in the literature, four of which have been bilateral9-’ The present report describes two further cases, both of which presented as stage I tumours. For the first time, neural elements are described in this variant, and cytogenetic analysis of a teratoid Wilms’ tumour is presented.
’.
Materials and methods Microscopic examination of each tumour was performed on formalin and Bouins-fixed, paraffin-embedded tissue. Both tumours were extensively sectioned for histological examination. Immunostaining was performed on 3 pm-thick sections cut from selected Bouins-fixed paraffin-embedded Address for correspondence: Dr J.F.Magee. Department of Anatomic and Surgical Pathology, British Columbia’s Children’s Hospital. 4480 Oak Street, Vancouver, British Columbia V6H 3V4. Canada.
blocks. An avidin-biotin technique was used for immunohistochemical stainingl2
