ORIGINAL ARTICLE
http://dx.doi.org/10.4046/trd.2015.78.3.253 ISSN: 1738-3536(Print)/2005-6184(Online) • Tuberc Respir Dis 2015;78:253-257
First Outcome of MDR-TB among Co-Infected HIV/TB Patients from South-West Iran
Mohammad Motamedifar, Ph.D.1,2, Hadi Sedigh Ebrahim-Saraie, Ph.D.1, Ali Reza Hassan Abadi, M.D.2 and Mahboube Nakhzari Moghadam, M.Sc.1
Department of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, 2Shiraz HIV/AIDS Research Center, Shiraz University of Medical Science, Shiraz, Iran 1
Background: Tuberculosis (TB) is the leading cause of mortality among human immunodeficiency virus (HIV) patients and the majority of them occur in developing countries. The aims of the present study were to determine the frequency of HIV/TB co-infection and other probable associated factors. Methods: This 10 year retrospective study was conducted on 824 HIV patients in the south-west of Iran. HIV infection was diagnosed by the enzyme linked immunosorbent assay and confirmed by Western blot. TB diagnosis was based on consistency of the clinical manifestations, chest X-ray, and microscopic examination. Drug susceptibility testing was done by the proportional method on Löwenstein-Jensen media. Results: Of 824 HIV patients, 59 (7.2%) were identified as TB co-infected and the majority (86.4%) of them were male. Of the overall TB infected patients, 6 cases (10.2%) showed multidrug-resistant with the mean CD4+ lymphocyte count of 163±166 cells/mm3. The main clinical forms of TB were pulmonary (73%). There was a significant (p
http://dx.doi.org/10.4046/trd.2015.78.3.253 ISSN: 1738-3536(Print)/2005-6184(Online) • Tuberc Respir Dis 2015;78:253-257
First Outcome of MDR-TB among Co-Infected HIV/TB Patients from South-West Iran
Mohammad Motamedifar, Ph.D.1,2, Hadi Sedigh Ebrahim-Saraie, Ph.D.1, Ali Reza Hassan Abadi, M.D.2 and Mahboube Nakhzari Moghadam, M.Sc.1
Department of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, 2Shiraz HIV/AIDS Research Center, Shiraz University of Medical Science, Shiraz, Iran 1
Background: Tuberculosis (TB) is the leading cause of mortality among human immunodeficiency virus (HIV) patients and the majority of them occur in developing countries. The aims of the present study were to determine the frequency of HIV/TB co-infection and other probable associated factors. Methods: This 10 year retrospective study was conducted on 824 HIV patients in the south-west of Iran. HIV infection was diagnosed by the enzyme linked immunosorbent assay and confirmed by Western blot. TB diagnosis was based on consistency of the clinical manifestations, chest X-ray, and microscopic examination. Drug susceptibility testing was done by the proportional method on Löwenstein-Jensen media. Results: Of 824 HIV patients, 59 (7.2%) were identified as TB co-infected and the majority (86.4%) of them were male. Of the overall TB infected patients, 6 cases (10.2%) showed multidrug-resistant with the mean CD4+ lymphocyte count of 163±166 cells/mm3. The main clinical forms of TB were pulmonary (73%). There was a significant (p
