Clinical Nutrition xxx (2015) 1e14
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Clinical Nutrition journal homepage: http://www.elsevier.com/locate/clnu
Meta-analyses
Systematic review and meta-analysis: Prevalence and possible causes of vitamin D deficiency and insufficiency in pediatric cancer patients R. Revuelta Iniesta a, b, *, R. Rush a, I. Paciarotti a, b, E.B. Rhatigan c, F.H.M. Brougham d, J.M. McKenzie a, D.C. Wilson b a
Dietetics, Nutrition and Biological Health Sciences, Queen Margaret University, Edinburgh, UK Department of Child Life and Health, University of Edinburgh, Edinburgh, UK Department of Paediatrics, Victoria Hospital, Kirkcaldy, Fife, UK d Department of Haematology and Oncology, Royal Hospital for Sick Children, Edinburgh, UK b c
a r t i c l e i n f o
s u m m a r y
Article history: Received 1 June 2014 Accepted 29 December 2014
Background and aims: Vitamin D inadequacy is now an internationally recognized health problem and pediatric cancer patients may be at even higher risk than healthy children. We aimed to evaluate primary research to establish the prevalence of vitamin D inadequacy and to explore its possible causes in pediatric cancer patients. Methods: Electronic databases were searched (no restriction-Aug 2013) with no language restrictions and keywords related to cancer and vitamin D. We included studies of patients aged 75 nmol/L or 30 ng/ml), insufficient (75e50 nmol/L or 30e20 ng/ml) and deficient (75 nmol/L Adequate: 50 e75 nmol/L Insufficiency: 25 e50 nmol/L Deficiency: