Synthesis, Characterization, and Antiinflammatory Activity of Naproxen Complexes With Rare Earth (IIII Zhong Ning Chen, Ru Wen Deng, and Ji Gui Wu Department of Chemistry, Lanzhou University, Lanzhou, People’s Republic of China

ABSTRACT RE(III)complexes of Naproxen(HNap) have been synthesized and characterized by elemental analyses, conductance measurements, solubilitiea, thermal analysis, infrared, proton magnetic resonance, and electronic spectral data. The elemental analyses reveal the presence of 1:3 (metakligand) stoichiometty and the IR spectra suggest the carboxylate group of HNap functions, as a bridging ligand to coordinate to RE(III) ions. The electronic spectra recorded in solid exhibit only slight shifts in visible regions, on which /3, 6 and bt of covalent parameters have been calculated. Formalin-induced rat paw edema and croton oil-induced rat ear edema inflammatory models were chosen to examine the antiiiammatory activity of Nd(III) complex, which ascertained enhanced antiinflammatory activity relative to the ligand.

INTRODUCTION is a nonsteroidal antiinflammatory analgesic useful in the treatment of artbritis and chronic and acute pain states [l]. Many studies show that although rare earth elements are not vital for biological systems, they have many pharmaceutical actions, such as antiinflammation, antibiosis, antitumor, anticoagulation, and depressing blood sugar [2-41. In recent years, many investigations for rare earth antiinflammatory drugs have been made, and some of them have been applied clinically [4]. So, it is worthwhile to undertake the synthesis, characterization, and antiinflammatory activity of HNap complexes with rare earth(lH) (Scheme 1): 0 0-M .* Naproxen(HNap)(I)

R-

Ho\

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l+C\,,H

/

+c

Synthesis, characterization, and antiinflammatory activity of naproxen complexes with rare earth (III).

RE(III) complexes of Naproxen(HNap) have been synthesized and characterized by elemental analyses, conductance measurements, solubilities, thermal ana...
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