Inflammation ( # 2014) DOI: 10.1007/s10753-014-9884-3

Synthesis and Pharmacological Evaluation of Carvacrol Propionate Marilia Trindade de Santana,1 Viviane Barros Silva,2 Renan Guedes de Brito,1 Priscila Laíse dos Santos,3 Sócrates Cabral de Holanda Cavalcanti,2 Emiliano Oliveira Barreto,4 Jamylle Nunes de Souza Ferro,4 Márcio Roberto Viana dos Santos,2 Adriano Antunes de Sousa Araújo,2 and Lucindo José Quintans-Júnior1,5

Abstract—This study aimed at synthesizing the carvacrol propionate (CP) and evaluating its pharmacological profile. CP was obtained from carvacrol and propionyl chloride through an esterification reaction. Male Swiss mice were treated with CP (25, 50, or 100 mg/kg). We evaluated the analgesic effect, mechanical hyperalgesia, and anti-inflammatory effect. Pre-treatment with CP inhibited (p

Synthesis and pharmacological evaluation of carvacrol propionate.

This study aimed at synthesizing the carvacrol propionate (CP) and evaluating its pharmacological profile. CP was obtained from carvacrol and propiony...
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