559
Hypocholesterolemic Activityof N-Diphenylmethylpiperazines
Synthesis and Hypocholesterolemic Activity of Some N-Diphenylmethylpiperazine Derlvatlves" Antonio Aliverr", Francese Canals", Juan-Julio Boner'", Vicente G6mez-Parrab,c:), and Felix Sanchez-Alonso'" ~ C.E.T.S. InstitutQufmicde Sarria,
Department of Organic: Chemistry.080l7-Barcelona. Spain Institutode Qufmica Organica (C.S.I.C.),Juan de la Cierva 3, 28006-Madrid. Spain c) Presentaddress:Centro National de Farmacobiologfa, 2822o-Majadahonda (Madrid). Spain
ReceivedJuly 25. 1990 Synthese und hypocholeslerolemischeAktivitat von einigen N·Diphenylmethylpiperazin-Derivaten
TIle synthesis and preliminary assays as hypocholesterolemic agentsof five N-diphenylmethylpiperazines are described. TIle evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the test employed. TIle di-p-chlorosubstituted compounds showed higher activity than their corresponding dechlorinated
FUnfN-Diphenylmethylpiperazine wurden synthetisiert und ihre hypochole-
sterolemische Aktivitllt an hypercholesterolaemischen Mllusen untersuchL Zwei Substanzen zeigten eine hl>here Aktivitllt als BezafibraL Die di-p-chlorosubstituienen Verbindungen warenaktiverals die dechlorienenAnaloga.
analogs.
= =
Fig.r
R
R
R
r-\
HN
CI
NH
Hypocholesterolemic Activityof N-Diphenylmethylpiperazines
Synthesis and Hypocholesterolemic Activity of Some N-Diphenylmethylpiperazine Derlvatlves" Antonio Aliverr", Francese Canals", Juan-Julio Boner'", Vicente G6mez-Parrab,c:), and Felix Sanchez-Alonso'" ~ C.E.T.S. InstitutQufmicde Sarria,
Department of Organic: Chemistry.080l7-Barcelona. Spain Institutode Qufmica Organica (C.S.I.C.),Juan de la Cierva 3, 28006-Madrid. Spain c) Presentaddress:Centro National de Farmacobiologfa, 2822o-Majadahonda (Madrid). Spain
ReceivedJuly 25. 1990 Synthese und hypocholeslerolemischeAktivitat von einigen N·Diphenylmethylpiperazin-Derivaten
TIle synthesis and preliminary assays as hypocholesterolemic agentsof five N-diphenylmethylpiperazines are described. TIle evaluations were carried out in hypercholesterolemic mice and two of these compounds were more effective than bezafibrate in the test employed. TIle di-p-chlorosubstituted compounds showed higher activity than their corresponding dechlorinated
FUnfN-Diphenylmethylpiperazine wurden synthetisiert und ihre hypochole-
sterolemische Aktivitllt an hypercholesterolaemischen Mllusen untersuchL Zwei Substanzen zeigten eine hl>here Aktivitllt als BezafibraL Die di-p-chlorosubstituienen Verbindungen warenaktiverals die dechlorienenAnaloga.
analogs.
= =
Fig.r
R
R
R
r-\
HN
CI
NH
