Accepted Manuscript Synchronous Lobular Carcinoma In Situ And Invasive Lobular Cancer: Marker or Precursor For Invasive Lobular Carcinoma A.S. Wallace, MD D. Xiang, MD L. Hockman, BS M. Arya, MD J. Jeffress, MS Z. Wang, MA P.S. Dale, MD PII:

S0748-7983(14)00422-3

DOI:

10.1016/j.ejso.2014.04.007

Reference:

YEJSO 3820

To appear in:

European Journal of Surgical Oncology

Received Date: 19 November 2013 Revised Date:

1 April 2014

Accepted Date: 11 April 2014

Please cite this article as: Wallace AS, Xiang D, Hockman L, Arya M, Jeffress J, Wang Z, Dale PS, Synchronous Lobular Carcinoma In Situ And Invasive Lobular Cancer: Marker or Precursor For Invasive Lobular Carcinoma, European Journal of Surgical Oncology (2014), doi: 10.1016/j.ejso.2014.04.007. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Title page Synchronous Lobular Carcinoma In Situ And Invasive Lobular Cancer: Marker or Precursor For Invasive Lobular Carcinoma

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Statement about content of paper: Little is reported about the incidence of lobular carcinoma in situ (LCIS) in specimens of invasive lobular cancer (ILC). We report a large coexistence of ILC with LCIS in a 10 year cohort of women.

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A.S. Wallace, MD 1 D. Xiang, MD 2 L. Hockman, BS 1 M. Arya, MD 2 J. Jeffress, MS 1 Z. Wang, MA 3 P.S. Dale, MD 4

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1. University of Missouri Hospitals and Clinics University of Missouri School of Medicine 1 Hospital Drive, MC520, DC116.94 Columbia, MO

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2. University of Missouri Hospitals and Clinics Division of Hematology Oncology 1 Hospital Drive, MC520, DC116.94 Columbia, MO

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3. University of Missouri Hospitals and Clinics Division of Hematology Oncology 1 Hospital Drive, MC520, DC116.94 Columbia, MO 4. Corresponding Author: P.S. Dale, MD University of Missouri Hospitals and Clinics 1 Hospital Drive, MC520, DC116.94 Columbia, MO Fax: 573-884-6054 Number: 573-882-8454 [email protected] Conflict of Interest: No authors have financial conflicts of interest.

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Abstract

AIM:

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Lobular carcinoma in situ (LCIS) is a known risk factor for invasive breast carcinoma, but there is increasing data indicating a possible precursor relationship. This study investigates the

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incidence of lobular carcinoma in situ that occurs with invasive lobular carcinoma (ILC).

METHODS:

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Women diagnosed with ILC or LCIS from 2000-2010 were retrospectively identified and reviewed after institutional review board approval. This group was divided into two cohorts: ILC alone, and LCIS and ILC (ILC/LCIS). Patient demographics, disease characteristics, and

RESULTS:

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treatment modalities were captured. P 2 cm in comparison to IDC. Despite this higher T stage, prognosis

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was better for ILC than the IDC cohort. [26] In the prior mentioned SEER analysis, Chuba et al. found that IBC diagnosed after LCIS was more likely to be smaller than primary IBC. [8] Hence, we postulated that our findings of smaller tumor size in ILC/LCIS was simply an earlier manifestation of invasive lobular disease. Despite the similar age at diagnosis, duration of follow-up, and overall recurrence rates between our two cohorts, patients were more likely to be

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dead at time of analysis with ILC than with the more indolent ILC/LCIS. If ILC/LCIS lesions were simply diagnosed earlier than their ILC counterparts, it is not unreasonable to assume

Weakness

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worse survival would be due to the more advanced nature of the disease.

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Although pathology specimens were reviewed by experienced pathologists at our institution, no centralized review was performed. It is possible that some cases may be changed today given the evolving diagnostic criteria of lobular disease, and understanding about the role of LCIS as a precursor and prognostic factor rather than a form of breast cancer. Also, given our short followup, we may not have provided enough time for detection of contralateral breast recurrences that are typically reported in studies with follow-up of 10 to 20 years. In the previously mentioned

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review of National Surgical Adjuvant Breast and Bowel Project (NSABP) patients, Fisher et al. found contralateral cancer recurrences occurred later than ipsilateral recurrences, with 70% identified after five years in comparison to 44% in ipsilateral breast. [27] Despite these

with pre-invasive and invasive lobular disease.

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Conclusion:

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weaknesses, this study adds valuable information regarding disease characteristics for patients

The presence of a pre-invasive disease may present precursor lesions to invasive carcinoma. The

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incidence of lobular carcinoma in situ in proximity to specimens of invasive lobular disease was high in our 10 year cohort of patients (47%). These findings are hypothesis generating, and

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further research is necessary to identify the relationship between in situ and invasive disease.

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References

the breast. Breast Cancer Res Treat. 2002;75:259-68.

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1. Li CI, Anderson BO, Daling JR et al. Changing incidence of lobular carcinoma in situ of

2. Li CI, Anderson BO, Porter P, Holt SK, Daling JR, Moe RE. Changing incidence rate of

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invasive lobular breast carcinoma among older women. Cancer. 2000 88:2561-9.

3. Cocquyt V, Van Belle S. Lobular carcinoma in situ and invasive lobular cancer of the

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breast. Curr Opin Obstet Gynecol. 2005;17:55-60.

4. Sapino A, Frigerio A, Peterse JL, et al. Mammographically detected in situ lobular carcinomas of the breast. Virchows Arch. 2000;436:421-30.

5. Georgian-Smith D, Lawton TJ. Calcifications of lobular carcinoma in situ of the breast:

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radiologic-pathologic correlation. AJR Am J Roentgenol. 2001;176:1255-9. 6. Page DL, Kidd TE Jr, Dupont WD et al. Lobular neoplasia of the breast: higher risk for subsequent invasive cancer predicted by more extensive disease. Hum Pathol.

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1991;22:1232-9.

7. Bratthauer GL, Tavassoli FA. Lobular intraepithelial neoplasia: previously unexplored

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aspects assessed in 775 cases and their clinical implications. Virchows Arch. 2002;440:134-8.

8. Chuba PJ, Hamre MR, Yap J. Bilateral risk for subsequent breast cancer after lobular carcinoma-in-situ: analysis of surveillance, epidemiology, and end results data. J Clin Oncol. 2005;23:5534-41. 9. Vos CB, Cleton-Jansen AM, Berx G. E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis. Br J Cancer. 1997;76:1131-3.

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10. De Leeuw WJ, Berx G, Vos CB et al. Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ. J Pathol. 1997;183:404-11. 11. Aulmann S, Penzel R, Longerich T et al. Clonality of lobular carcinoma in situ (LCIS)

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and metachronous invasive breast cancer. Breast Cancer Res Treat. 2008;107:331-5. 12. Hwang ES, Nyante SJ, Yi Chen Y et al. Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma. Cancer. 2004;100:2562-72.

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13. Mastracci TL, Shadeo A, Colby SM. Genomic alterations in lobular neoplasia: a microarray comparative genomic hybridization signature for early neoplastic

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proliferationin the breast. Genes Chromosomes Cancer. 2006;45:1007-17. 14. Andrade VP, Ostrovnaya I, Seshan VE. Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions. Breast Cancer Res. 2012;14:R103. 15. Bratthauer GL, Tavassoli FA. Assessment of lesions coexisting with various grades of

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ductal intraepithelial neoplasia of the breast. Virchows Arch. 2004;444:340-4. 16. Edge SB, American Joint Committee on Cancer, American Cancer Society: AJCC cancer staging handbook: From the AJCC cancer staging manual, 7th edition. New York:

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Springer; 2010.

17. Haagensen CD, Lane N, Lattes R. Lobular neoplasia (so-called lobular carcinoma in situ)

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of the breast. Cancer. 1978;42:737-69.

18. Bagaria SP, Shamonki J, Kinnaird M. The florid subtype of lobular carcinoma in situ: marker or precursor for invasive lobular carcinoma? Ann Surg Oncol. 2011;18:1845-51.

19. Buchanan CL, Flynn LW, Murray MP et al. Is pleomorphic lobular carcinoma really a distinct clinical entity? J Surg Oncol. 2008;98:314-7. 20. Frykberg ER. Lobular Carcinoma In Situ of the Breast. Breast J. 1999;5:296-303.

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21. Moran M, Haffty BG. Lobular carcinoma in situ as a component of breast cancer: the long-term outcome in patients treated with breast-conservation therapy. Int J Radiat Oncol Biol Phys. 1998;40:353-8.

with other breast lesions. Diagn Pathol. 2011;6:74.

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22. Gomes DS, Balabram D, Porto SS et al. Lobular neoplasia: frequency and association

23. Sasson AR, Fowble B, Hanlon AL et al. Lobular carcinoma in situ increases the risk of

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local recurrence in selected patients with stages I and II breast carcinoma treated with conservative surgery and radiation. Cancer. 2001;91:1862-9.

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24. Ottesen GL, Graversen HP, Blichert-Toft M et al. Carcinoma in situ of the female breast. 10 year follow-up results of a prospective nationwide study. Breast Cancer Res Treat. 2000;62:197-210.

25. Page DL, Schuyler PA, Dupont WD et al. Atypical lobular hyperplasia as a unilateral

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predictor of breast cancer risk: a retrospective cohort study. Lancet. 2003;361:125-9. Erratum in: Lancet. 2003;7;361:1994.

26. Wasif N, Maggard MA, Ko CY et al. Invasive lobular vs. ductal breast cancer: a stage-

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matched comparison of outcomes. Ann Surg Oncol. 2010;17:1862-9. 27. Fisher ER, Land SR, Fisher B et al. Pathologic findings from the National Surgical

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Adjuvant Breast and Bowel Project: twelve-year observations concerning lobular carcinoma in situ. Cancer. 2004;100:238-44.

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Table 1: Treatment and Surgical Pathology Characteristics by Histology ILC/LCIS (n=37) (41%) (32%) (22%) (5%)

0.54

(38%) (48%) (11%) (3%)

0.19

12 21 4

(32%) (57%) (11%)

0.33

17 18 2

(46%) (49%) (5%)

0.26

21 13 3

(57%) (35%) (8%)

0.80

15 (5-85)

--

0.03

14 19 1 3

(38%) (51%) (3%) (8%)

0.11

24 5 3 5

(65%) (13.5%) (8%) (13.5%)

0.75

14 18 4 1

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15 12 8 2

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AJCC Stage 1 11 (25%) 2 19 (43%) 3 11 (25%) 4 1 (2%) Other 2 (5%) Method of Initial Diagnosis Clinical Exam 23 (52%) Mammogram 17 (39%) Ultrasound 4 (9%) MRI Surgical Diagnosis Excisional 8 (18%) Core 31 (71%) Unknown or other 5 (11%) Surgical Extent Mastectomy 28 (64%) Less than Mastectomy 15 (34%) Biopsy 1 (2%) Lymph Node Evaluation Negative 22 (50%) Positive 17 (39%) Unknown 5 (11%) Tumor Size Largest Diameter(mm) 35 -(range) (n= 74) ( 1-110) Nuclear Grade Grade 1 16 (36%) Grade 2 14 (32%) Grade 3 4 (9%) Unknown 10 (23%) Margins Negative 29 (66%) Close (

Synchronous lobular carcinoma in situ and invasive lobular cancer: marker or precursor for invasive lobular carcinoma.

Lobular carcinoma in situ (LCIS) is a known risk factor for invasive breast carcinoma, but there is increasing data indicating a possible precursor re...
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