Clinical Ophthalmology
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Letter
Open Access Full Text Article
Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction This article was published in the following Dove Press journal: Clinical Ophthalmology 26 August 2017 Number of times this article has been viewed
Daniel Edward Robert Beck 1 Karim El-Assal 1 Ken McGarry 2 Nicholas Kloster Wride 1 Sunderland Eye Infirmary, Faculty of Health Sciences and Wellbeing, University of Sunderland, Sunderland, UK 1 2
Dear editor We read with interest the article by Negrete et al.1 A recent study performed at our unit found similar results on conducting a review of tolerance to preservative-free latanoprost (Monopost) in patients who were unable to tolerate preserved formulae, and we would like to take the opportunity to share the results with you. Notes were reviewed of 67 eyes in 35 patients started on Monopost who had shown intolerance to preserved latanoprost. It was noted that of these, only two were unable to continue the drug, demonstrating excellent tolerability. One patient stopped Monopost after 1 month, due to ocular surface discomfort. Another stopped after 7 months, as they felt the drops were the cause of their headache. The minimum follow-up was 8 months, with an average follow-up period of 15 months. We also analyzed intraocular pressure (IOP) readings and found the mean to be 20.1 mmHg using preserved latanoprost and 18.7 mmHg 6 weeks after switching to Monopost. A paired-sample t-test and Wilcoxon signed-rank test were performed, which demonstrated no significant difference between the effectiveness of the treatments (P=0.68, P=0.117). Given that these findings correlate well with the study by Negrete et al, we propose that it may not be necessary to perform an early IOP review 6 weeks after switching a patient from preserved latanoprost to Monopost, and so a patient could be followed up at their next routine glaucoma clinic visit. This new preparation of latanoprost appears to provide, therefore, significant benefits to patients, as well as a useful therapeutic option for physicians, which is most welcome.
Disclosure Correspondence: Daniel Edward Robert Beck Sunderland Eye Infirmary, Queen Alexandra Road, Sunderland SR2 9HP, UK Email [email protected]
The authors report no conflicts of interest in this communication.
submit your manuscript | www.dovepress.com
Clinical Ophthalmology 2017:11 1565–1566
Dovepress
© 2017 Beck et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
http://dx.doi.org/10.2147/OPTH.S143287
Reference
1. Negrete F, Lemij H, Erb C. Switching to preservative free latanoprost: impact on tolerability and patient satisfaction. Clin Ophthalmol. 2017;11:557–566.
1565
Dovepress
Beck et al
Dove Medical Press encourages responsible, free and frank academic debate. The content of the Clinical Ophthalmology ‘letters to the editor’ section does not necessarily represent the views of Dove Medical Press, its officers, agents, employees, related entities or the Clinical Ophthalmology editors. While all reasonable steps have been taken to confirm the content of each letter, Dove Medical Press accepts no liability in respect of the content of any letter, nor is it responsible for the content and accuracy of any letter to the editor.
Clinical Ophthalmology
Publish your work in this journal Clinical Ophthalmology is an international, peer-reviewed journal covering all subspecialties within ophthalmology. Key topics include: Optometry; Visual science; Pharmacology and drug therapy in eye diseases; Basic Sciences; Primary and Secondary eye care; Patient Safety and Quality of Care Improvements. This journal is indexed on
Dovepress PubMed Central and CAS, and is the official journal of The Society of Clinical Ophthalmology (SCO). The manuscript management system is completely online and includes a very quick and fair peer-review system, which is all easy to use. Visit http://www.dovepress.com/ testimonials.php to read real quotes from published authors.
Submit your manuscript here: http://www.dovepress.com/clinical-ophthalmology-journal
1566
submit your manuscript | www.dovepress.com
Dovepress
Clinical Ophthalmology 2017:11
Dovepress open access to scientific and medical research
Letter
Open Access Full Text Article
Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction This article was published in the following Dove Press journal: Clinical Ophthalmology 26 August 2017 Number of times this article has been viewed
Daniel Edward Robert Beck 1 Karim El-Assal 1 Ken McGarry 2 Nicholas Kloster Wride 1 Sunderland Eye Infirmary, Faculty of Health Sciences and Wellbeing, University of Sunderland, Sunderland, UK 1 2
Dear editor We read with interest the article by Negrete et al.1 A recent study performed at our unit found similar results on conducting a review of tolerance to preservative-free latanoprost (Monopost) in patients who were unable to tolerate preserved formulae, and we would like to take the opportunity to share the results with you. Notes were reviewed of 67 eyes in 35 patients started on Monopost who had shown intolerance to preserved latanoprost. It was noted that of these, only two were unable to continue the drug, demonstrating excellent tolerability. One patient stopped Monopost after 1 month, due to ocular surface discomfort. Another stopped after 7 months, as they felt the drops were the cause of their headache. The minimum follow-up was 8 months, with an average follow-up period of 15 months. We also analyzed intraocular pressure (IOP) readings and found the mean to be 20.1 mmHg using preserved latanoprost and 18.7 mmHg 6 weeks after switching to Monopost. A paired-sample t-test and Wilcoxon signed-rank test were performed, which demonstrated no significant difference between the effectiveness of the treatments (P=0.68, P=0.117). Given that these findings correlate well with the study by Negrete et al, we propose that it may not be necessary to perform an early IOP review 6 weeks after switching a patient from preserved latanoprost to Monopost, and so a patient could be followed up at their next routine glaucoma clinic visit. This new preparation of latanoprost appears to provide, therefore, significant benefits to patients, as well as a useful therapeutic option for physicians, which is most welcome.
Disclosure Correspondence: Daniel Edward Robert Beck Sunderland Eye Infirmary, Queen Alexandra Road, Sunderland SR2 9HP, UK Email [email protected]
The authors report no conflicts of interest in this communication.
submit your manuscript | www.dovepress.com
Clinical Ophthalmology 2017:11 1565–1566
Dovepress
© 2017 Beck et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
http://dx.doi.org/10.2147/OPTH.S143287
Reference
1. Negrete F, Lemij H, Erb C. Switching to preservative free latanoprost: impact on tolerability and patient satisfaction. Clin Ophthalmol. 2017;11:557–566.
1565
Dovepress
Beck et al
Dove Medical Press encourages responsible, free and frank academic debate. The content of the Clinical Ophthalmology ‘letters to the editor’ section does not necessarily represent the views of Dove Medical Press, its officers, agents, employees, related entities or the Clinical Ophthalmology editors. While all reasonable steps have been taken to confirm the content of each letter, Dove Medical Press accepts no liability in respect of the content of any letter, nor is it responsible for the content and accuracy of any letter to the editor.
Clinical Ophthalmology
Publish your work in this journal Clinical Ophthalmology is an international, peer-reviewed journal covering all subspecialties within ophthalmology. Key topics include: Optometry; Visual science; Pharmacology and drug therapy in eye diseases; Basic Sciences; Primary and Secondary eye care; Patient Safety and Quality of Care Improvements. This journal is indexed on
Dovepress PubMed Central and CAS, and is the official journal of The Society of Clinical Ophthalmology (SCO). The manuscript management system is completely online and includes a very quick and fair peer-review system, which is all easy to use. Visit http://www.dovepress.com/ testimonials.php to read real quotes from published authors.
Submit your manuscript here: http://www.dovepress.com/clinical-ophthalmology-journal
1566
submit your manuscript | www.dovepress.com
Dovepress
Clinical Ophthalmology 2017:11
