IOVS Papers in Press. Published on December 2, 2014 as Manuscript iovs.14-15667
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Susceptibility of Stenotrophomonas maltophilia Clinical Isolates to Antibiotics and
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Contact Lens Multipurpose Disinfecting Solutions
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Keizo Watanabe, 1,2 Hua Zhu,2,3 Mark Willcox3
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1. Department of Ophthalmology, Kinki University Faculty of Medicine, Osaka, Japan
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2. Brien Holden Vision Institute, Sydney, Australia
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3. School of Optometry and Vision Science, Sydney, Australia
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Commercial Relationships: Keizo Watanabe, None; Mark Willcox, None; Hua Zhu, None.
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Corresponding author: Mark Willcox
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Street Address:
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School of Optometry and Vision Science,
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The University of New South Wales,
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Sydney, NSW 2052
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Australia.
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Work tel: + 61293854164
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Fax: +612 93136243
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E-mail:
[email protected] 20 21
Short running header: Susceptibility of Stenotrophomonas maltophilia to antimicrobials
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Word count:
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1) Abstract: 174
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2) Text: 2009
Copyright 2014 by The Association for Research in Vision and Ophthalmology, Inc.
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Purpose: To determine the susceptibility of S. maltophilia to various antibiotics and contact
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lens multipurpose disinfecting solutions.
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Methods: Forty S. maltophilia strains from contact lens cases, contact lenses, or eye swabs of
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contact lens wearers including from 27 asymptomatic wearers and 13 keratitis patients were
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examined for their susceptibility to different antibiotics using a disc diffusion assay, and to
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multipurpose disinfecting solutions using a broth microdilution method.
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Results: Certain strains were resistant to aztreonum (15%), imipenem (93%),
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chroramphenicol (13%) and cefepime (8%). Two of those strains were multi-drug resistant.
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All strains were sensitive to trimethoprim-sulfamethoxazole, tigecycline, ceftazidime, and
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fluoroquinolones. Overall the MIC for all strains was significantly higher (p