IOVS Papers in Press. Published on December 2, 2014 as Manuscript iovs.14-15667

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Susceptibility of Stenotrophomonas maltophilia Clinical Isolates to Antibiotics and

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Contact Lens Multipurpose Disinfecting Solutions

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Keizo Watanabe, 1,2 Hua Zhu,2,3 Mark Willcox3

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1. Department of Ophthalmology, Kinki University Faculty of Medicine, Osaka, Japan

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2. Brien Holden Vision Institute, Sydney, Australia

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3. School of Optometry and Vision Science, Sydney, Australia

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Commercial Relationships: Keizo Watanabe, None; Mark Willcox, None; Hua Zhu, None.

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Corresponding author: Mark Willcox

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Street Address:

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School of Optometry and Vision Science,

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The University of New South Wales,

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Sydney, NSW 2052

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Australia.

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Work tel: + 61293854164

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Fax: +612 93136243

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E-mail: [email protected]

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Short running header: Susceptibility of Stenotrophomonas maltophilia to antimicrobials

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Word count:

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1) Abstract: 174

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2) Text: 2009

Copyright 2014 by The Association for Research in Vision and Ophthalmology, Inc.

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Purpose: To determine the susceptibility of S. maltophilia to various antibiotics and contact

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lens multipurpose disinfecting solutions.

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Methods: Forty S. maltophilia strains from contact lens cases, contact lenses, or eye swabs of

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contact lens wearers including from 27 asymptomatic wearers and 13 keratitis patients were

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examined for their susceptibility to different antibiotics using a disc diffusion assay, and to

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multipurpose disinfecting solutions using a broth microdilution method.

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Results: Certain strains were resistant to aztreonum (15%), imipenem (93%),

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chroramphenicol (13%) and cefepime (8%). Two of those strains were multi-drug resistant.

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All strains were sensitive to trimethoprim-sulfamethoxazole, tigecycline, ceftazidime, and

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fluoroquinolones. Overall the MIC for all strains was significantly higher (p

Susceptibility of Stenotrophomonas maltophilia clinical isolates to antibiotics and contact lens multipurpose disinfecting solutions.

To determine the susceptibility of Stenotrophomonas maltophilia to various antibiotics and contact lens multipurpose disinfecting solutions...
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