Angelsen et al. World Journal of Surgical Oncology 2014, 12:127 http://www.wjso.com/content/12/1/127
WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Surgery for colorectal liver metastases: the impact of resection margins on recurrence and overall survival Jon-Helge Angelsen1,2*, Arild Horn1, Geir Egil Eide3,4 and Asgaut Viste1,2
Abstract Background: Several reports have presented conflicting results regarding the association between resection margins (RMs) and outcome after surgery for colorectal liver metastases (CLM), especially in the era of modern chemotherapy. The purpose of this study was to evaluate the impact of RMs on overall survival (OS), time to recurrence (TTR) and local recurrence (LR) status, particularly for patients treated with preoperative chemotherapy. Methods: A combined retrospective (1998 to 2008) and prospective (2008 to 2010) cohort study of consecutive patients with CLM without extrahepatic disease treated with primary resection at a medium volume centre. Results: A total of 253 patients with known R status and 242 patients with defined margin width were included in the study. Patients were stratified according to margin width; A: R1,
WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Surgery for colorectal liver metastases: the impact of resection margins on recurrence and overall survival Jon-Helge Angelsen1,2*, Arild Horn1, Geir Egil Eide3,4 and Asgaut Viste1,2
Abstract Background: Several reports have presented conflicting results regarding the association between resection margins (RMs) and outcome after surgery for colorectal liver metastases (CLM), especially in the era of modern chemotherapy. The purpose of this study was to evaluate the impact of RMs on overall survival (OS), time to recurrence (TTR) and local recurrence (LR) status, particularly for patients treated with preoperative chemotherapy. Methods: A combined retrospective (1998 to 2008) and prospective (2008 to 2010) cohort study of consecutive patients with CLM without extrahepatic disease treated with primary resection at a medium volume centre. Results: A total of 253 patients with known R status and 242 patients with defined margin width were included in the study. Patients were stratified according to margin width; A: R1,
