MOLECULAR MEDICINE REPORTS 13: 2606-2612, 2016
2606
Superoxide dismutase activity and gene expression levels in Saudi women with recurrent miscarriage HAZEM K. GHNEIM1, YAZEED A. AL‑SHEIKH1, MASHAEL M. ALSHEBLY2 and MOURAD A. M. ABOUL‑SOUD1 1
Chair of Medical and Molecular Genetics, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433; 2Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh 11472, Kingdom of Saudi Arabia Received November 11, 2015; Accepted January 25, 2016 DOI: 10.3892/mmr.2016.4807 Abstract. The antioxidant activities of superoxide dismutase 1 (SOD1) and SOD2, as well as the levels of the oxidant superoxide anion (SOA) and the micronutrients zinc (Zn), copper (Cu) and manganese (Mn), were assayed in plasma, whole blood and placental tissue of non‑pregnant (NP), healthy pregnant (HP) women and recurrent miscarriage (RM) patients. The results showed that SOD1 and SOD2 activities and the levels of Zn, Cu and Mn in plasma and whole blood of HP women were slightly, but significantly lower, and even more significantly decreased in RM patients compared to those observed in NP women (P
2606
Superoxide dismutase activity and gene expression levels in Saudi women with recurrent miscarriage HAZEM K. GHNEIM1, YAZEED A. AL‑SHEIKH1, MASHAEL M. ALSHEBLY2 and MOURAD A. M. ABOUL‑SOUD1 1
Chair of Medical and Molecular Genetics, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433; 2Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh 11472, Kingdom of Saudi Arabia Received November 11, 2015; Accepted January 25, 2016 DOI: 10.3892/mmr.2016.4807 Abstract. The antioxidant activities of superoxide dismutase 1 (SOD1) and SOD2, as well as the levels of the oxidant superoxide anion (SOA) and the micronutrients zinc (Zn), copper (Cu) and manganese (Mn), were assayed in plasma, whole blood and placental tissue of non‑pregnant (NP), healthy pregnant (HP) women and recurrent miscarriage (RM) patients. The results showed that SOD1 and SOD2 activities and the levels of Zn, Cu and Mn in plasma and whole blood of HP women were slightly, but significantly lower, and even more significantly decreased in RM patients compared to those observed in NP women (P
