Original Article

Endocrinol Metab 2015;30:488-493 http://dx.doi.org/10.3803/EnM.2015.30.4.488 pISSN 2093-596X · eISSN 2093-5978

Subclinical Atherosclerosis in Patients with Cushing Syndrome: Evaluation with Carotid Intima-Media Thickness and Ankle-Brachial Index Luigi Petramala1, D’Elia Lorenzo1, Gino Iannucci1, Antonio Concistré1, Laura Zinnamosca1, Cristiano Marinelli1, Giuseppe De Vincentis2, Antonio Ciardi3, Giorgio De Toma3, Claudio Letizia1 Department of Internal Medicine and Medical Specialties, 2Section Nuclear Medicine, Department of Radiology, 3Department of Surgery, “P. Valdoni”, University of Rome “Sapienza”, Rome, Italy 1

Background: Cushing syndrome (CS) has been described as a killing disease due its cardiovascular complications. In fact, chronic cortisol excess leads to a constellation of complications, including hypertension, hyperglycemia, adiposity, and thromboembolism. The main vascular alteration associated with CS is atherosclerosis. Methods: Aim of this study was to analyze carotid intima-media thickness (cIMT) and ankle-brachial index (ABI), two surrogate markers of subclinical atherosclerosis in a consecutive series of CS patients, compared to patients with essential hypertension (EH) and health subjects (HS). Results: Patients with CS showed a significant increase (P

Subclinical Atherosclerosis in Patients with Cushing Syndrome: Evaluation with Carotid Intima-Media Thickness and Ankle-Brachial Index.

Cushing syndrome (CS) has been described as a killing disease due its cardiovascular complications. In fact, chronic cortisol excess leads to a conste...
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