RESEARCH ARTICLE

Stroke in HIV-infected individuals with and without HCV coinfection in Spain in the combination antiretroviral therapy era Alejandro Alvaro-Meca1, Juan Berenguer2,3☯*, Asuncio´n Dı´az4,5, Dariela Micheloud3,6, Teresa Alda´miz-Echevarrı´a2,3, Chiara Fanciulli2,3, Salvador Resino7☯

a1111111111 a1111111111 a1111111111 a1111111111 a1111111111

1 Unidad de Medicina Preventiva y Salud Pu´blica, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorco´n, Madrid, Spain, 2 Unidad de Enfermedades Infecciosas/VIH, Hospital General Universitario Gregorio Maraño´n, Madrid, Spain, 3 Instituto de Investigacio´n Sanitaria Gregorio Maraño´n (IiSGM), Madrid, ´ rea de Vigilancia Epidemiolo´gica de VIH/SIDA y comportamientos de riesgo, Centro Nacional de Spain, 4 A Epidemiologı´a, Instituto de Salud Carlos III, Madrid, Spain, 5 Centro de Investigacio´n Biome´dica en Red de Epidemiologı´a y Salud Pu´blica (CIBERESP), Madrid, Spain, 6 Servicio de Medicina Interna, Hospital General Universitario Gregorio Maraño´n, Madrid, Spain, 7 Unidad de Infeccio´n Viral e Inmunidad, Centro Nacional de Microbiologı´a, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain ☯ These authors contributed equally to this work. * [email protected]

OPEN ACCESS Citation: Alvaro-Meca A, Berenguer J, Dı´az A, Micheloud D, Alda´miz-Echevarrı´a T, Fanciulli C, et al. (2017) Stroke in HIV-infected individuals with and without HCV coinfection in Spain in the combination antiretroviral therapy era. PLoS ONE 12(6): e0179493. https://doi.org/10.1371/journal. pone.0179493 Editor: Sarah L Pett, University of New South Wales, AUSTRALIA Received: November 17, 2016 Accepted: May 31, 2017 Published: June 15, 2017 Copyright: © 2017 Alvaro-Meca et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported by grants from “Instituto de Salud Carlos III” (grant numbers PI14/ 01094, and PI14CIII/00011) and Red Española de Investigacio´n en SIDA (RIS, AIDS Research Network; grant numbers RD16/0025/0017, and RD16CIII/0002/0002). This study was (partially) funded by the RD16/0025 project as part of the

Abstract The incidence of stroke in human immunodeficiency virus (HIV)–infected individuals has been well analyzed in recent epidemiological studies. However, little is known about the specific contribution of hepatitis C virus (HCV) infection to stroke among HIV-infected individuals. The aims of this study were to analyze trends in the incidence rates of stroke in HIVinfected individuals during the combination antiretroviral (cART) era in Spain and to categorize them by the presence or absence of HCV coinfection. We analyzed hospital discharges with a diagnosis of stroke in Spain according to ICD-9-CM during 1997–2013. The study period was divided into four calendar periods (1997–1999, 2000–2003, 2004–2007, and 2008–2013). Patients were classified according to HCV serology. The number of HIVinfected patients was estimated based on data from the National Centre of Epidemiology. We calculated incidence rates (events per 10,000 patient-years) and in-hospital case fatality rates (CFR). The incidence of hemorrhagic stroke (HS) decreased in HIV-monoinfected patients (15.8 [1997–1999] to 6.5 [2008–2013]; P

Stroke in HIV-infected individuals with and without HCV coinfection in Spain in the combination antiretroviral therapy era.

The incidence of stroke in human immunodeficiency virus (HIV)-infected individuals has been well analyzed in recent epidemiological studies. However, ...
3MB Sizes 1 Downloads 7 Views