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Accepted Article

Stem cell therapy for bone repair: a systematic review and meta-analysis of preclinical studies with large animal model1

Running head: Stem cell therapy for bone repair: a systematic review Yun Liao1,2†, Xiao-Long Zhang3†, Ling Li1, Fu-Ming Shen1*, Ming-Kang Zhong2*, 1

Department of Clinical Pharmacy, Shanghai Tenth People’s Hospital, Tongji

University School of Medicine, Shanghai 200072, China

2

Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai 200040,

China 3

Department of Urology, Shanghai Tenth People’s Hospital, Tongji University School

of Medicine, Shanghai 200072, China

†These authors contributed equally to this work

*Corresponding authors.

Correspondence: Ming-Kang Zhong Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai 200040, China

Postal address: WuLuMuQi Middle Road 12, Shanghai 200040, China. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/bcp.12382

This article is protected by copyright. All rights reserved.

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Accepted Article

E-mail address: [email protected] Tel: +86 2166302570 Fax: +86 2166307668

Fu Ming Shen Department of Clinical Pharmacy, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China Postal address: 301 Yanchang Road Shanghai, Shanghai Tenth People's Hospital, Shanghai, 200072, China. E-mail address: [email protected] The word count: 2623 The numbers of tables: 3 the numbers of figures: 4

This article is protected by copyright. All rights reserved.

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Accepted Article

Abstract Aim

Injury to bone is a significant clinical challenge, due to its limited regenerative capacity. The current methods of repairing bone defect are surgical, highly invasive, and not always successful. A systematic review and meta-analysis of preclinical studies involving large animals with bone defects were conducted to determine the treatment outcomes with stem cell therapies. Methods A random effects meta-analysis of the available studies was conducted to assess the treatment outcomes including the rate of new bone formation and new bone mineral density (BMD). Stratified analyses were also conducted by separating studies based on each characteristic independently. Results

Pooled analysis of 20 preclinical studies showed significant beneficial effect of stem cell therapy in increasing new bone formation (17.79%; 95% confidence interval [CI], 10.54-25.03; P

Stem cell therapy for bone repair: a systematic review and meta-analysis of preclinical studies with large animal models.

Injury to bone is a significant clinical challenge, due to its limited regenerative capacity. The current methods of repairing bone defect are surgica...
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