ANESTHESIA AND ANALGESIA . . . Current Researches VoL. 56, No. 3, MAY-JUNE,1977
391
Sodium Nitroprusside-Produced Hypote nsio n During Anesthesia and Operation in the Head-Up Position ROBERT
K. STOELTING, MD"
OSCAR VIEGAS, M D t ROBERT L. CAMPBELL, M D $ Indianapolis, Indiana5
Measurements before, during, and a f t e r prolonged hypotension (148 ? 40 min, mean & SE) produced by sodium nitroprusside (SNP, 2.4 & 1.1 pg/kg/min) were obtained from 5 anesthetized adult patients in the head-up position. Reduction of mean arterial pressure (MAP) from 81 t o 54 torr ( a t t h e level of the circle of Willis) while maintaining similar concentrations of N20 and halothane was associated with a n unchanged arterial oxygenation and pH, decreased systemic vascular resistance (p