RESEARCH ARTICLE
Sleep Related Breathing Disorders and Inflammation — The Missing Link? A Cohort Study Evaluating the Interaction of Inflammation and Sleep Related Breathing Disorders and Effects of Treatment Natascha Troester1*, Michael Palfner1, Erich Schmidberger2, Horst Olschewski1,3, Alexander Avian2,3 1 Division of Pulmonology, Department of Internal Medicine, Medical University, Graz, Austria, 2 Institute for Medical Informatics, Statistics and Documentation, Medical University, Graz, Austria, 3 Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria * [email protected]
Abstract OPEN ACCESS Citation: Troester N, Palfner M, Schmidberger E, Olschewski H, Avian A (2015) Sleep Related Breathing Disorders and Inflammation — The Missing Link? A Cohort Study Evaluating the Interaction of Inflammation and Sleep Related Breathing Disorders and Effects of Treatment. PLoS ONE 10(9): e0137594. doi:10.1371/journal.pone.0137594 Editor: Andreas Zirlik, University Heart Center Freiburg, GERMANY
Introduction Sleep related breathing disorders (SRBD) are associated with both obesity and systemic inflammation. While the relationship between obesity and SRBD is established, the causality between inflammation and SRBD remains unclear. In this study we investigated the relation between SRBD and C-reactive protein (CRP) as a parameter of inflammation and the influence of SRBD treatment on CRP with additional regard to changes in metabolic and cardiovascular parameters.
Received: April 25, 2015
Methods
Accepted: August 18, 2015
Polysomnography (PSG) and laboratory data of patients diagnosed with SRBD over a period of 5 years were prospectively collected in a database and retrospectively analysed regarding the association of SRBD (according to apnoea-hypopnoea- index (AHI), duration of events and extent of desaturation) to CRP, blood pressure, cholesterol, fasting plasma glucose, HbA1c, quality of life measured via a visual analogue scale (VAS 0–100%), and the effects of SRBD therapy on these parameters.
Published: September 10, 2015 Copyright: © 2015 Troester et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors received no specific funding for this work. Competing Interests: The authors have declared that no competing interests exist.
Results 716 patients were included in the study, 171 with mild SRBD (AHI 5 to
Sleep Related Breathing Disorders and Inflammation — The Missing Link? A Cohort Study Evaluating the Interaction of Inflammation and Sleep Related Breathing Disorders and Effects of Treatment Natascha Troester1*, Michael Palfner1, Erich Schmidberger2, Horst Olschewski1,3, Alexander Avian2,3 1 Division of Pulmonology, Department of Internal Medicine, Medical University, Graz, Austria, 2 Institute for Medical Informatics, Statistics and Documentation, Medical University, Graz, Austria, 3 Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria * [email protected]
Abstract OPEN ACCESS Citation: Troester N, Palfner M, Schmidberger E, Olschewski H, Avian A (2015) Sleep Related Breathing Disorders and Inflammation — The Missing Link? A Cohort Study Evaluating the Interaction of Inflammation and Sleep Related Breathing Disorders and Effects of Treatment. PLoS ONE 10(9): e0137594. doi:10.1371/journal.pone.0137594 Editor: Andreas Zirlik, University Heart Center Freiburg, GERMANY
Introduction Sleep related breathing disorders (SRBD) are associated with both obesity and systemic inflammation. While the relationship between obesity and SRBD is established, the causality between inflammation and SRBD remains unclear. In this study we investigated the relation between SRBD and C-reactive protein (CRP) as a parameter of inflammation and the influence of SRBD treatment on CRP with additional regard to changes in metabolic and cardiovascular parameters.
Received: April 25, 2015
Methods
Accepted: August 18, 2015
Polysomnography (PSG) and laboratory data of patients diagnosed with SRBD over a period of 5 years were prospectively collected in a database and retrospectively analysed regarding the association of SRBD (according to apnoea-hypopnoea- index (AHI), duration of events and extent of desaturation) to CRP, blood pressure, cholesterol, fasting plasma glucose, HbA1c, quality of life measured via a visual analogue scale (VAS 0–100%), and the effects of SRBD therapy on these parameters.
Published: September 10, 2015 Copyright: © 2015 Troester et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors received no specific funding for this work. Competing Interests: The authors have declared that no competing interests exist.
Results 716 patients were included in the study, 171 with mild SRBD (AHI 5 to
