Acta orthop. scand. 47, 509-514, 1976
SKELETAL MALFORMATIONS INDUCED BY MITOMYCIN C
IN CHICK EMBRYOS J. D. SINGH & SHAMER SINGH
Acta Orthop 1976.47:509-514. Downloaded from informahealthcare.com by UB Kiel on 10/27/14. For personal use only.
Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
One hundred and eighty chick embryos were studied f o r the presence of skeletal malformations after administration of mitomycin C a t 72, 96 and 120 hours of incubation. Axial skeleton defects included those of ribs, vertebrae, beak and crania. Appendicular skeletal defects were mainly confined to the lower limbs e.g. absence of phalanges, bent and shortened femur, fibula, tibia and metatarsus, in that order. Absence of phalanges and curved scapulae were noted i n the upper limbs. The length of femur, tibia and metatarsus was significantly 0.001) compared with the corresponding controls espereduced ( P cially i n the group treated a t 96 h.
SKELETAL MALFORMATIONS INDUCED BY MITOMYCIN C
IN CHICK EMBRYOS J. D. SINGH & SHAMER SINGH
Acta Orthop 1976.47:509-514. Downloaded from informahealthcare.com by UB Kiel on 10/27/14. For personal use only.
Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
One hundred and eighty chick embryos were studied f o r the presence of skeletal malformations after administration of mitomycin C a t 72, 96 and 120 hours of incubation. Axial skeleton defects included those of ribs, vertebrae, beak and crania. Appendicular skeletal defects were mainly confined to the lower limbs e.g. absence of phalanges, bent and shortened femur, fibula, tibia and metatarsus, in that order. Absence of phalanges and curved scapulae were noted i n the upper limbs. The length of femur, tibia and metatarsus was significantly 0.001) compared with the corresponding controls espereduced ( P cially i n the group treated a t 96 h.
