ANESTH ANALG 1990;70:1%-90
185
Should We Inhibit Gastric Acid Secretion Before Cardiac Surgery? Jean Jacques Lehot, MD, Robert Deleat-Besson, MD, Olivier Bastien, Yvonne Brun, MD, Patrick Adeleine, MD, Jacques Robin, MD, and Suzanne Estanove, MD LEHOT JJ, DELEAT-BESSON R, BASTIEN 0, BRUN Y, ADELEINE P, ROBIN J, ESTANOVE S. Should we inhibit gastric acid secretion before cardiac surgery? Anesth Analg 1990;70:185-90.
Stress can decrease intragastric pH and cause erosion of gastric mucosa. Because cardiac surgery and cardiopulmonay bypass represent a major stress, the effects on intragastric pH of an HI-receptor antagonist, ranitidine, and an M,-muscarinic antagonist, pirenzepine, were evaluated. lntragastric pH was measured throughout elective cardiac surgery in 60 patients by a digital pH-meter during fentanyl-diazepam-nitrous oxide (50%) anesthesia. The gastric content was sampled at closure of the chest for bacterial count. Oral preoperative medication given randomly included ( n = 20 in each group) 0.3 mglkg diazepam 1 It before induction (group 1); diazepam plus ranitidine (150 mg) 1 h before induction (group 2); and diazepam plus pirenzepine (50 mg) on the evening bejore surgery and 2 h before induction of anesthesia (group 3).
Cardiac surgery and cardiopulmonary bypass (CPB) cause major stress. Thus they might increase gastric acid secretion and cause stress erosion of the gastric mucosa when intragastric pH (IG pH) is
185
Should We Inhibit Gastric Acid Secretion Before Cardiac Surgery? Jean Jacques Lehot, MD, Robert Deleat-Besson, MD, Olivier Bastien, Yvonne Brun, MD, Patrick Adeleine, MD, Jacques Robin, MD, and Suzanne Estanove, MD LEHOT JJ, DELEAT-BESSON R, BASTIEN 0, BRUN Y, ADELEINE P, ROBIN J, ESTANOVE S. Should we inhibit gastric acid secretion before cardiac surgery? Anesth Analg 1990;70:185-90.
Stress can decrease intragastric pH and cause erosion of gastric mucosa. Because cardiac surgery and cardiopulmonay bypass represent a major stress, the effects on intragastric pH of an HI-receptor antagonist, ranitidine, and an M,-muscarinic antagonist, pirenzepine, were evaluated. lntragastric pH was measured throughout elective cardiac surgery in 60 patients by a digital pH-meter during fentanyl-diazepam-nitrous oxide (50%) anesthesia. The gastric content was sampled at closure of the chest for bacterial count. Oral preoperative medication given randomly included ( n = 20 in each group) 0.3 mglkg diazepam 1 It before induction (group 1); diazepam plus ranitidine (150 mg) 1 h before induction (group 2); and diazepam plus pirenzepine (50 mg) on the evening bejore surgery and 2 h before induction of anesthesia (group 3).
Cardiac surgery and cardiopulmonary bypass (CPB) cause major stress. Thus they might increase gastric acid secretion and cause stress erosion of the gastric mucosa when intragastric pH (IG pH) is
