Accepted Manuscript Serum trace elements in dysphagic gastrostomy candidates before endoscopic gastrostomy for long term enteral feeding Carla Adriana Santos, MSc, Dietitian, Jorge Fonseca, MD, PhD, Elisabete Carolino, PhD, António Sousa Guerreiro, MD, PhD PII:

S0261-5614(15)00138-7

DOI:

10.1016/j.clnu.2015.05.006

Reference:

YCLNU 2579

To appear in:

Clinical Nutrition

Received Date: 16 February 2015 Revised Date:

4 May 2015

Accepted Date: 14 May 2015

Please cite this article as: Santos CA, Fonseca J, Carolino E, Guerreiro AS, Serum trace elements in dysphagic gastrostomy candidates before endoscopic gastrostomy for long term enteral feeding, Clinical Nutrition (2015), doi: 10.1016/j.clnu.2015.05.006. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT Title Page

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Serum trace elements in dysphagic gastrostomy candidates before endoscopic

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gastrostomy for long term enteral feeding

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Carla Adriana Santos, Dietitian MSc1; Jorge Fonseca, MD, PhD1,2; Elisabete Carolino,

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PhD3; António Sousa Guerreiro, MD, PhD4

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1

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Silva, 2800 Almada, Portugal

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CiiEM – Center for Interdisciplinary Research Egas Moniz, 2800 Almada, Portugal.

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Departamento das Ciências Naturais e Exatas, Área Científica de Matemática. Escola

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M AN U

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GENE – Enteral Feeding Team. Hospital Garcia de Orta. Av. Professor Torrado da

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Superior de Tecnologias da Saúde de Lisboa, Instituto Politécnico de Lisboa. 1990

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Lisboa

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Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo dos Mártires

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da Pátria, 130, 1169-056 Lisboa and Serviço de Med 4/Hospital Santa Marta/Centro

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Hospitalar de Lisboa Central, Rua de Santa Marta 50-1169-024 Lisboa, Portugal"

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Centro de Estudos de Doenças Crónicas, CEDOC, NOVA Medical School /

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16 Corresponding Author:

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Carla Adriana da Cunha Santos

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GENE - Grupo de Estudo de Nutrição Entérica. Bloco de Exame Especiais - Hospital

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Garcia de Orta. Av. Professor Torrado da Silva, 2800 Almada, Portugal

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+351917194386

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[email protected]

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ACCEPTED MANUSCRIPT Abstract

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Background & aims: Patients who underwent endoscopic gastrostomy (PEG)

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present protein-energy malnutrition, but little is known about Trace Elements

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(TE), Zinc (Zn), Copper (Cu), Selenium (Se), Iron (Fe), Chromium (Cr). Our aim

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was the evaluation of serum TE in patients who underwent PEG and its

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relationship with serum proteins, BMI and nature of underlying disorder.

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Methods: A prospective observational study was performed collecting: patient’s

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age, gender, underlying disorder, NRS-2002, BMI, serum albumin, transferrin

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and TE concentration. We used ferrozine colorimetric method for Fe; Inductively

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Coupled Plasma-Atomic Emission Spectroscopy for Zn/Cu; Furnace Atomic

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Absorption Spectroscopy for Se/Cr. The patients were divided into head and

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neck cancer (HNC) and neurological dysphagia (ND).

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Results: 146 patients (89 males), 21-95 years: HNC-56; ND-90. Low BMI in 78.

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Low values mostly for Zn (n=122) and Fe (n=69), but less for Se (n=31), Cu

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(n=16), Cr (n=7); low albumin in 77, low transferrin in 94 and 66 with both

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proteins low. Significant differences between the groups of underlying disease

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only for Zn (t140.326= –2,642, p

Serum trace elements in dysphagic gastrostomy candidates before endoscopic gastrostomy for long term enteral feeding.

Patients who underwent endoscopic gastrostomy (PEG) present protein-energy malnutrition, but little is known about Trace Elements (TE), Zinc (Zn), Cop...
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