Int J Clin Exp Med 2015;8(10):19471-19475 www.ijcem.com /ISSN:1940-5901/IJCEM0012679
Original Article Serum somatostatin and neuron-specific enolase might be biochemical markers of vascular dementia in the early stage Yan Shen, Huan-Min Gao Department of Neurology, Ningxia People’s Hospital, Northwest University for Nationalities, Yinchuan 750002, China Received July 9, 2015; Accepted October 12, 2015; Epub October 15, 2015; Published October 30, 2015 Abstract: Objectives: To estimate whether serum somatostatin (SS) and neuron-specific enolase (NSE), the representative neuropeptide relative to learning and memory, to be biochemical markers of the vascular dementia (VaD) in the early stage. Methods: 42 patients with VaD were randomized in the VaD group and 38 stroke patients without dementia was in the control group. Radioimmunoassay was used to detect SS in the serum and CSF, and Enzyme linked immunosorbent assay to detect NSE in the serum and CSF. SS and NSE in CSF were compared 3 days after stroke. SS and NSE contends in serum were compared 3 days, 3 months and 6 months poststroke. Results: CSF and serum SS contents in VaD group were lower than that in the control group (P
Original Article Serum somatostatin and neuron-specific enolase might be biochemical markers of vascular dementia in the early stage Yan Shen, Huan-Min Gao Department of Neurology, Ningxia People’s Hospital, Northwest University for Nationalities, Yinchuan 750002, China Received July 9, 2015; Accepted October 12, 2015; Epub October 15, 2015; Published October 30, 2015 Abstract: Objectives: To estimate whether serum somatostatin (SS) and neuron-specific enolase (NSE), the representative neuropeptide relative to learning and memory, to be biochemical markers of the vascular dementia (VaD) in the early stage. Methods: 42 patients with VaD were randomized in the VaD group and 38 stroke patients without dementia was in the control group. Radioimmunoassay was used to detect SS in the serum and CSF, and Enzyme linked immunosorbent assay to detect NSE in the serum and CSF. SS and NSE in CSF were compared 3 days after stroke. SS and NSE contends in serum were compared 3 days, 3 months and 6 months poststroke. Results: CSF and serum SS contents in VaD group were lower than that in the control group (P
