Journal of Infectious Diseases Advance Access published April 24, 2015
1 Serum Procalcitonin and Viral Testing to Guide Antibiotic Use for Respiratory Infections in Hospitalized Adults: A Randomized Control Trial
Andrea Baran4, Derick R. Peterson4, and Ann R. Falsey1,2 of Medicine, University of Rochester, Rochester, NY
2Department
of Medicine, Rochester General Hospital, Rochester, NY
3Department
of Laboratory Sciences, Rochester General Hospital, Rochester, NY
4Department
of Biostatistics and Computational Biology, University of Rochester, Rochester, NY
Author: Angela R. Branche, MD, Infectious Disease Unit, University of Rochester, 601
an
*Corresponding
us
1Department
Elmwood Avenue, Rochester, NY, 14642 USA, FAX: 585-442-9328, Phone: 585-275-5871, Email:
Ac
ce
pt ed
M
angela_branche @urmc.rochester.edu
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected].
Downloaded from http://jid.oxfordjournals.org/ at Mount Allison University on July 27, 2015
cr ipt
Angela R. Branche1,*, Edward E. Walsh1,2, Roberto Vargas3, Barbara Hulbert3, Maria A. Formica2,
2 Abstract Background: Viral lower respiratory tract illness (LRTI) frequently causes adult hospitalization and is
cr ipt
linked to antibiotic overuse. European studies suggest serum procalcitonin (PCT) may be used to guide antibiotic therapy. We conducted a trial assessing the feasibility of using PCT algorithms with viral testing to guide antibiotic use in a US hospital. ClinicalTrials.gov (NCT01907659)
Methods: 300 patients hospitalized with non-pneumonic LRTI from October 2013-April 2014 were
randomized 1:1 to standard care or PCT-guided care and viral PCR testing. The primary outcome was
us
Results: Viruses were identified in 42% and 80% of intervention subjects had PCT values
1 Serum Procalcitonin and Viral Testing to Guide Antibiotic Use for Respiratory Infections in Hospitalized Adults: A Randomized Control Trial
Andrea Baran4, Derick R. Peterson4, and Ann R. Falsey1,2 of Medicine, University of Rochester, Rochester, NY
2Department
of Medicine, Rochester General Hospital, Rochester, NY
3Department
of Laboratory Sciences, Rochester General Hospital, Rochester, NY
4Department
of Biostatistics and Computational Biology, University of Rochester, Rochester, NY
Author: Angela R. Branche, MD, Infectious Disease Unit, University of Rochester, 601
an
*Corresponding
us
1Department
Elmwood Avenue, Rochester, NY, 14642 USA, FAX: 585-442-9328, Phone: 585-275-5871, Email:
Ac
ce
pt ed
M
angela_branche @urmc.rochester.edu
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected].
Downloaded from http://jid.oxfordjournals.org/ at Mount Allison University on July 27, 2015
cr ipt
Angela R. Branche1,*, Edward E. Walsh1,2, Roberto Vargas3, Barbara Hulbert3, Maria A. Formica2,
2 Abstract Background: Viral lower respiratory tract illness (LRTI) frequently causes adult hospitalization and is
cr ipt
linked to antibiotic overuse. European studies suggest serum procalcitonin (PCT) may be used to guide antibiotic therapy. We conducted a trial assessing the feasibility of using PCT algorithms with viral testing to guide antibiotic use in a US hospital. ClinicalTrials.gov (NCT01907659)
Methods: 300 patients hospitalized with non-pneumonic LRTI from October 2013-April 2014 were
randomized 1:1 to standard care or PCT-guided care and viral PCR testing. The primary outcome was
us
Results: Viruses were identified in 42% and 80% of intervention subjects had PCT values
