Scandinavian Journal of Gastroenterology
ISSN: 0036-5521 (Print) 1502-7708 (Online) Journal homepage: http://www.tandfonline.com/loi/igas20
Serum Pepsinogen I and Serum Gastrin in the Screening of Atrophic Pangastritis with High Risk of Gastric Cancer K. Varis, M. Kekki, M. Härkönen, P. Sipponen & I. M. Samloff To cite this article: K. Varis, M. Kekki, M. Härkönen, P. Sipponen & I. M. Samloff (1991) Serum Pepsinogen I and Serum Gastrin in the Screening of Atrophic Pangastritis with High Risk of Gastric Cancer, Scandinavian Journal of Gastroenterology, 26:sup186, 117-123, DOI: 10.3109/00365529109103998 To link to this article: http://dx.doi.org/10.3109/00365529109103998
Published online: 08 Jul 2009.
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Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=igas20 Download by: [University of New England]
Date: 16 March 2016, At: 18:07
Serum Pepsinogen I and Serum Gastrin in the Screening of Atrophic Pangastritis with High Risk of Gastric Cancer K. VARIS, M. KEKKI, M. HARKONEN, P. SIPPONEN & I.M. SAMLOFF Malmintori Medical Center, Helsinki, Second Dept. of Medicine, University of Helsinki, Helsinki, United Laboratories, Helsinki, Jorvi Hospital, Espoo, Finland, and Veterans Administration Medical Center, Sepulveda, CA, USA
Downloaded by [University of New England] at 18:07 16 March 2016
Varis K, Kekki M, Harkonen M, Sipponen P, Samloff IM. Serum pepsinogen 1 and serum gastrin in the screening of atrophic pangastritis with high risk of gastric cancer. Scand J Gastroenterol 1991, 26 (suppl 186), 117-123 Serum pepsinogen I (S-PGI) and serum gastrin (S-gastrin) were examined in the screening of three types of atrophic gastritis with inherent high risk of gastric cancer: in 102 cases with severe atrophic corpus gastritis (SACG), in 5 cases with severe atrophic antrum gastritis (SAAG), and in 15 cases with severe atrophic pangastritis (SAPG) (atrophy both in corpus and in antrum) found among 916 subjects from three family series (265 from gastric cancer families, 425 from randomly selected control families and 226 from pernicious anaemia families). There is no way to screen directly atrophic gastritis restricted to the antral mucosa. In pangastritis atrophy of antral glands causes a failure of the hypcrgastrinemic reaction of achlorhydria. The Combination of S-PGI
ISSN: 0036-5521 (Print) 1502-7708 (Online) Journal homepage: http://www.tandfonline.com/loi/igas20
Serum Pepsinogen I and Serum Gastrin in the Screening of Atrophic Pangastritis with High Risk of Gastric Cancer K. Varis, M. Kekki, M. Härkönen, P. Sipponen & I. M. Samloff To cite this article: K. Varis, M. Kekki, M. Härkönen, P. Sipponen & I. M. Samloff (1991) Serum Pepsinogen I and Serum Gastrin in the Screening of Atrophic Pangastritis with High Risk of Gastric Cancer, Scandinavian Journal of Gastroenterology, 26:sup186, 117-123, DOI: 10.3109/00365529109103998 To link to this article: http://dx.doi.org/10.3109/00365529109103998
Published online: 08 Jul 2009.
Submit your article to this journal
Article views: 10
View related articles
Citing articles: 2 View citing articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=igas20 Download by: [University of New England]
Date: 16 March 2016, At: 18:07
Serum Pepsinogen I and Serum Gastrin in the Screening of Atrophic Pangastritis with High Risk of Gastric Cancer K. VARIS, M. KEKKI, M. HARKONEN, P. SIPPONEN & I.M. SAMLOFF Malmintori Medical Center, Helsinki, Second Dept. of Medicine, University of Helsinki, Helsinki, United Laboratories, Helsinki, Jorvi Hospital, Espoo, Finland, and Veterans Administration Medical Center, Sepulveda, CA, USA
Downloaded by [University of New England] at 18:07 16 March 2016
Varis K, Kekki M, Harkonen M, Sipponen P, Samloff IM. Serum pepsinogen 1 and serum gastrin in the screening of atrophic pangastritis with high risk of gastric cancer. Scand J Gastroenterol 1991, 26 (suppl 186), 117-123 Serum pepsinogen I (S-PGI) and serum gastrin (S-gastrin) were examined in the screening of three types of atrophic gastritis with inherent high risk of gastric cancer: in 102 cases with severe atrophic corpus gastritis (SACG), in 5 cases with severe atrophic antrum gastritis (SAAG), and in 15 cases with severe atrophic pangastritis (SAPG) (atrophy both in corpus and in antrum) found among 916 subjects from three family series (265 from gastric cancer families, 425 from randomly selected control families and 226 from pernicious anaemia families). There is no way to screen directly atrophic gastritis restricted to the antral mucosa. In pangastritis atrophy of antral glands causes a failure of the hypcrgastrinemic reaction of achlorhydria. The Combination of S-PGI
