Wiklund et al. Diabetology & Metabolic Syndrome 2014, 6:40 http://www.dmsjournal.com/content/6/1/40
DIABETOLOGY & METABOLIC SYNDROME
RESEARCH
Open Access
Serum metabolic profiles in overweight and obese women with and without metabolic syndrome Petri K Wiklund1,2, Satu Pekkala1, Reija Autio3, Eveliina Munukka1, Leiting Xu4, Juha Saltevo5, ShuMei Cheng1, Urho M Kujala1, Markku Alen2,6 and Sulin Cheng1*
Abstract Objective: To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body weight and fat mass. Methods: We applied nuclear magnetic resonance spectroscopy-based profiling of fasting serum samples to examine the metabolic differences between 78 previously physically inactive, body weight and fat mass matched overweight/obese premenopausal women with and without MetS. MetS was defined as the presence of at least three of the following five criteria: waist circumference ≥88 cm, serum triacylglycerol ≥1.7 mmol/L, and high density lipoprotein cholesterol (HDL-C)
DIABETOLOGY & METABOLIC SYNDROME
RESEARCH
Open Access
Serum metabolic profiles in overweight and obese women with and without metabolic syndrome Petri K Wiklund1,2, Satu Pekkala1, Reija Autio3, Eveliina Munukka1, Leiting Xu4, Juha Saltevo5, ShuMei Cheng1, Urho M Kujala1, Markku Alen2,6 and Sulin Cheng1*
Abstract Objective: To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body weight and fat mass. Methods: We applied nuclear magnetic resonance spectroscopy-based profiling of fasting serum samples to examine the metabolic differences between 78 previously physically inactive, body weight and fat mass matched overweight/obese premenopausal women with and without MetS. MetS was defined as the presence of at least three of the following five criteria: waist circumference ≥88 cm, serum triacylglycerol ≥1.7 mmol/L, and high density lipoprotein cholesterol (HDL-C)
