Tumor Biol. DOI 10.1007/s13277-013-1506-4

RESEARCH ARTICLE

Serum levels of osteopontin as a prognostic factor in patients with oral squamous cell carcinoma Maryam Mardani & Azadeh Andisheh-Tadbir & Bijan Khademi & Mohammad Javad Fattahi & Shapour Shafiee & Maryam Asad-Zadeh

Received: 2 November 2013 / Accepted: 3 December 2013 # International Society of Oncology and BioMarkers (ISOBM) 2013

Abstract Osteopontin (OPN) is a multifunctional glycophosphoprotein that was detected in many carcinomas, and it may have a prognostic role. The aim of this study was to determine osteopontin serum levels in patients with oral squamous cell carcinoma (OSCC) and investigated its correlation with clinicopathological features of tumor. Using an ELISA kit, we assessed and compared the circulating levels of OPN in blood serum of 45 oral squamous cell carcinoma patients with 45 healthy control

M. Mardani Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran A. Andisheh-Tadbir Oral and Dental Health Care Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran B. Khademi Department of Otolaryngology, Khalili Hospital, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran M. J. Fattahi Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran S. Shafiee School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran A. Andisheh-Tadbir (*) : M. Asad-Zadeh Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Ghom Abad, Ghasrodasht Avenue, Shiraz, Iran e-mail: [email protected] A. Andisheh-Tadbir e-mail: [email protected]

samples. The serum osteopontin level in patients with OSCC was significantly higher (145.8±14.6 ng/ml, n =45) compared with the healthy controls (53.9±9.6 ng/ml, n =45, p

Serum levels of osteopontin as a prognostic factor in patients with oral squamous cell carcinoma.

Osteopontin (OPN) is a multifunctional glycophosphoprotein that was detected in many carcinomas, and it may have a prognostic role. The aim of this st...
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