Serial measurements of platelet angiotensin II binding in two patients with hypertension in pregnancy: Case reports Philip N. Baker, DM, and Fiona Broughton Pipkin, DPhil Nottingham, England Serial estimations of platelet angiotensin II binding were made in two patients with hypertension developing in the third trimester of pregnancy. The fall in platelet angiotensin II binding that is seen in normotensive pregnancy did not occur in these two patients. (AM J OesTET GVNECOL 1992;167:487-8.)

Key words: Angiotensin II, platelet membrane glycoproteins, pregnancy toxemia, renin-angiotensin system Two patients were recruited to a longitudinal study (n == 30) of platelet angiotensin II binding in normo-

tensive pregnancy. In one of these patients platelet angiotensin II binding was measured before conception. Hypertension developed subsequently, and thus they were excluded from the original study. Neither woman was known to have renal, metabolic, or cardiovascular disease. Both patients were receiving unrestricted sodium intake and on recruitment to the study had normal serum urea, creatinine, and electrolyte values. In both patients serial platelet counts and plasma creatinine and urate levels were measured, with serial estimations of platelet angiotensin II binding and plasma angiotensin II concentration being performed, as previously described.'

Case reports Case 1. A 28-year-old normotensive nulliparous woman was initially studied on day 6 of the menstrual cycle. She conceived 3 months later and was then studied at intervals during her pregnancy. She remained normotensive (diastolic blood pressure