Epilepsio, 33(2):235-247, 1992 Raven Press, Ltd., New York 0 International League Against Epilepsy
Seizure Activity in Pyridoxine-Deficient Adult Rats S. K. Sharma and K. Dakshinamurti Department of Biochemistry and Molecular Biology, Faculty of Medicine, University o f Manitoba, Winnipeg, Manitoba, Canada
Summary: This investigation tested the hypothesis that the degree of pyridoxine depletion rather than the status of neuronal maturity determines seizure proneness in the pyridoxine-deficient rat. Dietary pyridoxine deficiency was induced in neuronally mature rats. Seizure activity was monitored using computerized EEG analysis. Dietary pyridoxine deficiency of 10 weeks’ duration induced in neuronally mature rats led to spontaneous convulsive seizure activity. Even moderately pyridoxinedeficient adult rats (on the deficient diet for
Seizure Activity in Pyridoxine-Deficient Adult Rats S. K. Sharma and K. Dakshinamurti Department of Biochemistry and Molecular Biology, Faculty of Medicine, University o f Manitoba, Winnipeg, Manitoba, Canada
Summary: This investigation tested the hypothesis that the degree of pyridoxine depletion rather than the status of neuronal maturity determines seizure proneness in the pyridoxine-deficient rat. Dietary pyridoxine deficiency was induced in neuronally mature rats. Seizure activity was monitored using computerized EEG analysis. Dietary pyridoxine deficiency of 10 weeks’ duration induced in neuronally mature rats led to spontaneous convulsive seizure activity. Even moderately pyridoxinedeficient adult rats (on the deficient diet for
