410 TRANSACTIONS OFTHEROYALSOCIETY OFTROPICAL MEDIC~EANDHYGIENE (1992)
Schistosome circulating Schistosoma japonicum with praziquantel A. B. Van ‘t Wout’, Parasitology, Medical Parasitology, College Walter and Eliza Hall
86, 41CL413
anodic antigen in serum of individuals infected with from The Philippines before and after chemotherapy
N. De Jonge’, W. U. Tiu2, E. E. Garcia2, G. F. Mitchell3 and A. M. Deelder’ lLaborutoty lLaboratoty of Faculty, University University of Leiden, P.O. Box 9605, 2300 RC Leiden, The Netherlands; 2Department of of Public Health, University of The Philippines, P.O. Box EA460 Manila, The Philippines; 3The Institute ofMedical Research, Melbourne, Victoria 3050, Australia
Abstract The presence of the schistosome circulating anodic antigen (CAA) in serum of patients infected with Schistosoma japonicum from The Philippines has been investigated using an enzyme-linked immunosorbent assay (ELISA). Serum samples were tested from 48 patients who excreted S. japonicum eggs, 9 individuals with a negative stool examination, and 20 controls with both a negative stool and a negative circumoval precipitin test. No false positive result was detected for the unequivocally negative controls. CAA could be demonstrated in 72.9% of the egg-excreting patients. A positive correlation between parasite burden (eggs per gram of faeces) and antigen level (CAA titre) was found (Spearman’s p=O.48, P
Schistosome circulating Schistosoma japonicum with praziquantel A. B. Van ‘t Wout’, Parasitology, Medical Parasitology, College Walter and Eliza Hall
86, 41CL413
anodic antigen in serum of individuals infected with from The Philippines before and after chemotherapy
N. De Jonge’, W. U. Tiu2, E. E. Garcia2, G. F. Mitchell3 and A. M. Deelder’ lLaborutoty lLaboratoty of Faculty, University University of Leiden, P.O. Box 9605, 2300 RC Leiden, The Netherlands; 2Department of of Public Health, University of The Philippines, P.O. Box EA460 Manila, The Philippines; 3The Institute ofMedical Research, Melbourne, Victoria 3050, Australia
Abstract The presence of the schistosome circulating anodic antigen (CAA) in serum of patients infected with Schistosoma japonicum from The Philippines has been investigated using an enzyme-linked immunosorbent assay (ELISA). Serum samples were tested from 48 patients who excreted S. japonicum eggs, 9 individuals with a negative stool examination, and 20 controls with both a negative stool and a negative circumoval precipitin test. No false positive result was detected for the unequivocally negative controls. CAA could be demonstrated in 72.9% of the egg-excreting patients. A positive correlation between parasite burden (eggs per gram of faeces) and antigen level (CAA titre) was found (Spearman’s p=O.48, P
