International Journal of Laboratory Hematology The Official journal of the International Society for Laboratory Hematology
ORIGINAL ARTICLE
INTERNAT IONAL JOURNAL OF LABORATO RY HEMATO LOGY
Schistocytes in disseminated intravascular coagulation J.-F. LESESVE* 1 , M. MARTIN*, C. BANASIAK*, E. ANDR E-KERNE€IS † 1 , V. BARDET ‡ 1 , D. LUSINA § 1 , A. KHARBACH ¶ , F. GENEVI EVE** 1 , T. LECOMPTE † †
*Hematology laboratories at Nancy, Nancy, France † Hematology laboratories at Meaux, Meaux, France ‡ Hematology laboratories at Paris Cochin, Paris Cochin, France § Hematology laboratories at Paris Avicenne, Paris Avicenne, France ¶ Hematology laboratories at Neufchateau, Neufchateau, France **Hematology laboratories at Angers hospitals, Angers, France †† Hematology division, Geneva, Swizerland Correspondence: Jean-Francßois Lesesve, Service d’Hematologie Biologique, CHU Nancy, 54 511, Vandoeuvre, France. Tel.: 03 83 15 37 66; Fax: 03 83 15 37 89; E-mail: [email protected]
S U M M A RY Introduction: The presence of schistocytes on the peripheral blood film during disseminated intravascular coagulation (DIC) remains controversial. Methods: We examined schistocytes count on blood films from 35 DIC patients and checked morphological anomalies of all RBCs. Results: Thirty of 35 patients presented with schistocytes and 22 with acanthocytes, which was the commonest shape anomaly. Mean percentage standard deviation was 0.33 0.38%, median value was 0.1%, and range was 0–1.4%. The patients with schistocytes ≥ 1% had circumstances frequently associated with increased schistocytes count (promyelocytic leukaemia, pregnancy, severe infection). Discussion: Schistocytes were thus frequently observed in DIC patients, usually with low percentage, within or close to the reference range (
ORIGINAL ARTICLE
INTERNAT IONAL JOURNAL OF LABORATO RY HEMATO LOGY
Schistocytes in disseminated intravascular coagulation J.-F. LESESVE* 1 , M. MARTIN*, C. BANASIAK*, E. ANDR E-KERNE€IS † 1 , V. BARDET ‡ 1 , D. LUSINA § 1 , A. KHARBACH ¶ , F. GENEVI EVE** 1 , T. LECOMPTE † †
*Hematology laboratories at Nancy, Nancy, France † Hematology laboratories at Meaux, Meaux, France ‡ Hematology laboratories at Paris Cochin, Paris Cochin, France § Hematology laboratories at Paris Avicenne, Paris Avicenne, France ¶ Hematology laboratories at Neufchateau, Neufchateau, France **Hematology laboratories at Angers hospitals, Angers, France †† Hematology division, Geneva, Swizerland Correspondence: Jean-Francßois Lesesve, Service d’Hematologie Biologique, CHU Nancy, 54 511, Vandoeuvre, France. Tel.: 03 83 15 37 66; Fax: 03 83 15 37 89; E-mail: [email protected]
S U M M A RY Introduction: The presence of schistocytes on the peripheral blood film during disseminated intravascular coagulation (DIC) remains controversial. Methods: We examined schistocytes count on blood films from 35 DIC patients and checked morphological anomalies of all RBCs. Results: Thirty of 35 patients presented with schistocytes and 22 with acanthocytes, which was the commonest shape anomaly. Mean percentage standard deviation was 0.33 0.38%, median value was 0.1%, and range was 0–1.4%. The patients with schistocytes ≥ 1% had circumstances frequently associated with increased schistocytes count (promyelocytic leukaemia, pregnancy, severe infection). Discussion: Schistocytes were thus frequently observed in DIC patients, usually with low percentage, within or close to the reference range (
