Journal of Periodontology; Copyright 2014
DOI: 10.1902/jop.2014.140581
Salivary and Serum Leptin Concentrations in Patients With Chronic Periodontitis Dr. Parth Purwar BDS, MDS*, Dr. M.A. Khan BDS, MDS, Professor*, Dr. Abbas Ali Mahdi Ph.D, Professor and Head†, Dr. Shivani Pandey M.Sc, Ph.D, Assistant Professor†, Babita Singh Ph.D Scholar†, Dr. Jaya Dixit BDS, MDS, Professor & Head*, Dr. Sagar Sareen BDS, Post graduate student* *
Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Lucknow, Uttar Pradesh, India. †
Department of Biochemistry, King George’s Medical University, Lucknow, Uttar Pradesh, India.
Background: The discovery of leptin has led to the elucidation of a robust physiologic system that not only maintains fat stores but is also an integral part of the host defence mechanism. However, the leptin concentration in the saliva of chronic periodontitis patients has not been explored despite the potential role of salivary biomarkers in determining the presence, risk and progression of periodontal diseases. Materials and Methods: Eighty four participants (44 with generalized severe chronic periodontitis and 40 healthy) were accrued. For each patient, the values of periodontal parameters, such as plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment loss (CA loss),% of sites with bleeding on probing (BOP+) and % of sites with CA loss > 5 mm were recorded. Saliva and serum samples were collected to estimate the leptin levels using enzyme linked immunosorbent assay kits. Statistical analysis was performed using the statistical software. Results: Participants with chronic periodontitis (CP) demonstrated significantly higher BOP+, PI, GI and % of sites with CA loss > 5mm (p 90%. Volunteer Characteristics: Table 1 reveals that there were no statistically significant differences (p>0.05) between the two groups in terms of age, gender, education, SES, BMI, number of teeth present in the oral cavity and frequency of tooth brushing. Clinical Parameters: All the periodontal clinical parameters (PI, GI, PD and CA loss) were significantly higher (p 5mm and sites which shows BOP + were significantly higher in group A (p
DOI: 10.1902/jop.2014.140581
Salivary and Serum Leptin Concentrations in Patients With Chronic Periodontitis Dr. Parth Purwar BDS, MDS*, Dr. M.A. Khan BDS, MDS, Professor*, Dr. Abbas Ali Mahdi Ph.D, Professor and Head†, Dr. Shivani Pandey M.Sc, Ph.D, Assistant Professor†, Babita Singh Ph.D Scholar†, Dr. Jaya Dixit BDS, MDS, Professor & Head*, Dr. Sagar Sareen BDS, Post graduate student* *
Department of Periodontology, Faculty of Dental Sciences, King George’s Medical University, Lucknow, Uttar Pradesh, India. †
Department of Biochemistry, King George’s Medical University, Lucknow, Uttar Pradesh, India.
Background: The discovery of leptin has led to the elucidation of a robust physiologic system that not only maintains fat stores but is also an integral part of the host defence mechanism. However, the leptin concentration in the saliva of chronic periodontitis patients has not been explored despite the potential role of salivary biomarkers in determining the presence, risk and progression of periodontal diseases. Materials and Methods: Eighty four participants (44 with generalized severe chronic periodontitis and 40 healthy) were accrued. For each patient, the values of periodontal parameters, such as plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment loss (CA loss),% of sites with bleeding on probing (BOP+) and % of sites with CA loss > 5 mm were recorded. Saliva and serum samples were collected to estimate the leptin levels using enzyme linked immunosorbent assay kits. Statistical analysis was performed using the statistical software. Results: Participants with chronic periodontitis (CP) demonstrated significantly higher BOP+, PI, GI and % of sites with CA loss > 5mm (p 90%. Volunteer Characteristics: Table 1 reveals that there were no statistically significant differences (p>0.05) between the two groups in terms of age, gender, education, SES, BMI, number of teeth present in the oral cavity and frequency of tooth brushing. Clinical Parameters: All the periodontal clinical parameters (PI, GI, PD and CA loss) were significantly higher (p 5mm and sites which shows BOP + were significantly higher in group A (p
