MOLECULAR MEDICINE REPORTS 11: 400-404, 2015
400
Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis ZHIYUAN WU1*, BIN LIU1,2*, CAILING E3,4*, JIE LIU1, QINGYU ZHANG1, JUNTAO LIU5, NIANPING CHEN2, RONGYI CHEN3 and RUNZHI ZHU2 1
Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical College; 2Laboratory of Hepatobiliary Surgery, Guangdong Medical College, Zhanjiang Key Laboratory of Hepatobiliary Diseases; 3 Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001; 4 Department of Dermatology, Affiliated People's Hospital of Hubei University of Medicine, Shiyan, Hubei 442000; 5 The Second Department of Orthopedics, Ningde Hospital, Affiliated Hospital of Fujian Medical University, Ningde, Fujian 352100, P.R. China Received January 6, 2014; Accepted July 22, 2014 DOI: 10.3892/mmr.2014.2716 Abstract. Resveratrol (Res), a natural plant extract, is an effective inducer of cell apoptosis and cell cycle arrest in multiple carcinoma cell types, which has been demonstrated by its ability to inhibit the proliferation of multiple human tumor cells in vitro. Although Res possesses chemopreventive properties against several types of cancer, the molecular mechanism underlying its anticancer activity remains to be fully elucidated. The present study demonstrated that Res induced cell cycle arrest and inhibited the proliferation of human melanoma A375 (IC50=23 µM after 48 h; P
400
Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis ZHIYUAN WU1*, BIN LIU1,2*, CAILING E3,4*, JIE LIU1, QINGYU ZHANG1, JUNTAO LIU5, NIANPING CHEN2, RONGYI CHEN3 and RUNZHI ZHU2 1
Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical College; 2Laboratory of Hepatobiliary Surgery, Guangdong Medical College, Zhanjiang Key Laboratory of Hepatobiliary Diseases; 3 Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001; 4 Department of Dermatology, Affiliated People's Hospital of Hubei University of Medicine, Shiyan, Hubei 442000; 5 The Second Department of Orthopedics, Ningde Hospital, Affiliated Hospital of Fujian Medical University, Ningde, Fujian 352100, P.R. China Received January 6, 2014; Accepted July 22, 2014 DOI: 10.3892/mmr.2014.2716 Abstract. Resveratrol (Res), a natural plant extract, is an effective inducer of cell apoptosis and cell cycle arrest in multiple carcinoma cell types, which has been demonstrated by its ability to inhibit the proliferation of multiple human tumor cells in vitro. Although Res possesses chemopreventive properties against several types of cancer, the molecular mechanism underlying its anticancer activity remains to be fully elucidated. The present study demonstrated that Res induced cell cycle arrest and inhibited the proliferation of human melanoma A375 (IC50=23 µM after 48 h; P
