Role of the Renin-Angiotensin-AldosteroneSystem in HypertensiveChildren With Coarctation of the Aorta
BRUCES. ALPERT,MD HUGHH. BAIN, MB J. WILLIAMSONBALFE, MD B. S. LANGFORDKIDD, MD, FACC PETERM. OLLEY, MB, FACC Toronto, Ontario, Canada
From the Divisions of Cardiology and Nephrology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada. This study was supported by Grant 4-10 from the Ontario Heart Foundation, Toronto, Ontario. Manuscript received August 4, 1978; revised manuscript received November 6, 1978, accepted November 9. 1978. Address for reprints: Peter M. Olley, MB, Division of Cardiology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
828
April 1979
To investigate the role of the renin-angiotensin-aidosterone system as a cause of hypertension, 20 hypertensive patients with coarctation of the aorta were studied during normal and low sodium tntake and after diuresis with furosemide. Etght patients wtth essential hypertension and 13 control subjects were similarly studied. Plasma renin activity values in patients with coarctation were similar to those in patients with essential hypertension and in control patients during normal and low sodium diets. However, after the administration of furosemide, plasma renin activity values were signtftcantiy higher in the patients with coarctation than in the other two groups (P CO.005 and