1 Clinical Infectious Diseases Advance Access published June 16, 2015
Risk Factors Associated with Infant Deaths from Pertussis: A Case-Control Study Kathleen Winter1, Jennifer Zipprich1, Kathleen Harriman1, Erin L. Murray1, Jeffrey Gornbein2,
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Sandra Jo Hammer1, Nava Yeganeh3, Kristina Adachi3, James D. Cherry3 1
Immunization Branch, California Department of Public Health SBCC – Department of Biomathematics, David Geffen School of Medicine at UCLA 3 Department of Pediatrics, David Geffen School of Medicine at UCLA
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Alternative Corresponding Author: Kathleen Winter, MPH, California Department of Public Health Immunization Branch, 850 Marina Bay Parkway, P2-357 Richmond, CA 94804, E-mail: [email protected], Phone: 1-510-620-3770, Fax: 1-510-620-3949
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Summary:
Ac
ce
pt ed
Fifty-three fatal infant pertussis cases were identified and compared with 183 nonfatal hospitalized pertussis cases. In multivariate analyses, higher peak WBC count, lower birth weight, intubation, and receipt of nitric oxide were predictors of death.
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected].
Downloaded from http://cid.oxfordjournals.org/ at North Dakota State University on July 6, 2015
Corresponding Author: James D. Cherry MD, MSc Department of Pediatrics, David Geffen School of Medicine at UCLA 10833 Le Conte Ave. MDCC 22-442, Los Angeles, CA 90095-1752 E-mail: [email protected], Phone: 1-310-825-5226, Fax: 1-310-206-4764
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ABSTRACT - Word count: 250 Background In the current era, most pertussis deaths occur in infants less than 3 months of age. Leukocytosis
cr ipt
with lymphocytosis and pneumonia are commonly observed among severe pertussis cases. Methods
Risk factors associated with fatal pertussis were identified by comparing fatal pertussis cases
Risk Factors Associated with Infant Deaths from Pertussis: A Case-Control Study Kathleen Winter1, Jennifer Zipprich1, Kathleen Harriman1, Erin L. Murray1, Jeffrey Gornbein2,
cr ipt
Sandra Jo Hammer1, Nava Yeganeh3, Kristina Adachi3, James D. Cherry3 1
Immunization Branch, California Department of Public Health SBCC – Department of Biomathematics, David Geffen School of Medicine at UCLA 3 Department of Pediatrics, David Geffen School of Medicine at UCLA
2
us
an
Alternative Corresponding Author: Kathleen Winter, MPH, California Department of Public Health Immunization Branch, 850 Marina Bay Parkway, P2-357 Richmond, CA 94804, E-mail: [email protected], Phone: 1-510-620-3770, Fax: 1-510-620-3949
M
Summary:
Ac
ce
pt ed
Fifty-three fatal infant pertussis cases were identified and compared with 183 nonfatal hospitalized pertussis cases. In multivariate analyses, higher peak WBC count, lower birth weight, intubation, and receipt of nitric oxide were predictors of death.
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected].
Downloaded from http://cid.oxfordjournals.org/ at North Dakota State University on July 6, 2015
Corresponding Author: James D. Cherry MD, MSc Department of Pediatrics, David Geffen School of Medicine at UCLA 10833 Le Conte Ave. MDCC 22-442, Los Angeles, CA 90095-1752 E-mail: [email protected], Phone: 1-310-825-5226, Fax: 1-310-206-4764
2
ABSTRACT - Word count: 250 Background In the current era, most pertussis deaths occur in infants less than 3 months of age. Leukocytosis
cr ipt
with lymphocytosis and pneumonia are commonly observed among severe pertussis cases. Methods
Risk factors associated with fatal pertussis were identified by comparing fatal pertussis cases
