Accepted Manuscript Revisiting outcomes of right congenital diaphragmatic hernia Adesola C. Akinkuotu, MD, Stephanie M. Cruz, MD, Darrell L. Cass, MD, Christopher I. Cassady, MD, Amy R. Mehollin-Ray, MD, Jennifer L. Williams, MD, Timothy C. Lee, MD, Rodrigo Ruano, MD PhD, Stephen E. Welty, MD, Oluyinka O. Olutoye, MD PhD PII:

S0022-4804(15)00355-8

DOI:

10.1016/j.jss.2015.03.090

Reference:

YJSRE 13259

To appear in:

Journal of Surgical Research

Received Date: 6 January 2015 Revised Date:

20 March 2015

Accepted Date: 27 March 2015

Please cite this article as: Akinkuotu AC, Cruz SM, Cass DL, Cassady CI, Mehollin-Ray AR, Williams JL, Lee TC, Ruano R, Welty SE, Olutoye OO, Revisiting outcomes of right congenital diaphragmatic hernia, Journal of Surgical Research (2015), doi: 10.1016/j.jss.2015.03.090. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT Revised: 3/20/15

Revisiting outcomes of right congenital diaphragmatic hernia

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Adesola C. Akinkuotu MD1, Stephanie M. Cruz MD1, Darrell L. Cass MD1,2, Christopher I. Cassady MD3, Amy R. Mehollin-Ray MD3, Jennifer L. Williams MD3, Timothy C. Lee MD1; Rodrigo Ruano MD PhD2, Stephen E. Welty MD4, Oluyinka O. Olutoye MD PhD1,2

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Affiliations: Texas Children’s Fetal Center and the Michael E. DeBakey Department of Surgery1 and Department of Obstetrics and Gynecology2, Radiology3, and Pediatrics - Newborn Section4, Baylor College of Medicine, Houston, TX

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Author Contributions: Adesola C. Akinkuotu and Oluyinka O. Olutoye: Drs. Akinkuotu and Olutoye conceptualized and designed the case report, drafted the initial manuscript, reviewed and revised the manuscript and approved the final manuscript as submitted. Stephanie Cruz, Darrell L. Cass, Timothy C. Lee, Christopher I. Cassady, Amy R. Mehollin-Ray, Jennifer L. Williams, Rodrigo Ruano and Stephen E. Welty,: Drs. Cruz, Cass, Lee, Cassady, Mehollin-Ray, Williams, Ruano and Welty reviewed and revised the manuscript, and approved the final manuscript as submitted.

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Disclosures: The authors report no proprietary or commercial interest in any product mentioned or concept discussed in this article.

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Please address correspondence to: Oluyinka O. Olutoye, MD PhD Texas Children’s Hospital 6701 Fannin St, Suite 1210 Houston, TX 77030 [[email protected]] 832-822-3135

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ACCEPTED MANUSCRIPT Revised: 3/20/15

Abstract:

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Introduction: Studies comparing outcomes of right- and left-sided congenital diaphragmatic hernia (R-CDH and L-CDH) have yielded conflicting results. We hypothesized that R-CDH is associated with higher short-term pulmonary morbidity than L-CDH.

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Methods: We reviewed all CDH patients at a tertiary children’s hospital over 10 years. In prenatally diagnosed CDH, the observed-to-expected total fetal lung volume (O/E- TFLV) and percentage liver herniation (%LH) were calculated using fetal MRI-based measurements. Outcomes were compared in patients with isolated CDH. Patients were subsequently matched by %LH to compare outcomes.

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Results: Of 189 CDH patients; 37 (20.1 %) were R-CDH and 147 (79.9%) were L-CDH. Those with R-CDH were prenatally diagnosed at a significantly lower rate (40.5%vs.73.5%; p

Revisiting outcomes of right congenital diaphragmatic hernia.

Studies comparing outcomes of right- and left-sided congenital diaphragmatic hernia (R-CDH and L-CDH) have yielded conflicting results. We hypothesize...
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