Letter to the Editor Stroke welcomes Letters to the Editor and will publish them, if suitable, as space permits. Letters must reference a Stroke published-ahead-of-print article or an article printed within the past 3 weeks. The maximum length is 750 words including no more than 5 references and 3 authors. Please submit letters typed double-spaced. Letters may be shortened or edited.
Response to Letter Regarding Article, “Tenecteplase–Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke with Proven Occlusion”
We thank Dr Behrouz1 for their letter. We are in agreement that further trials of tenecteplase in stroke are needed, but are cautious about making conclusions based on comparisons of noncontemporaneous controls. The Tenecteplase–Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke With Proven Occlusion (TEMPO-2) study2 will examine the effect of tenecteplase versus control among patients with minor stroke and proven intracranial occlusion. We think that it critical to add the element of noninvasive vascular imaging to studies of thrombolytic agents. We are looking forward to beginning the study in the second quarter of 2015.
Acknowledgments Study drug for the TEMPO-1 trial was provided by Hoffman-La Roche Canada.
Disclosures None.
Shelagh B. Coutts, MD, FRCPC Michael D. Hill, MD, FRCPC Departments of Clinical Neurosciences and Radiology Hotchkiss Brain Institute University of Calgary Calgary, Alberta, Canada
1. Behrouz R, Mutgi SA, Silver B. Letter by Behrouz et al regarding article, “Tenecteplase–tissue-type plasminogen activator evaluation for minor ischemic stroke with proven occlusion.” Stroke. 2015;46:e149. doi: 10.1161/STROKEAHA.115.009193. 2. Clinical Trials.gov. A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion (TEMPO-2). Clinical Trials.gov Web site. https://clinicaltrials.gov/ct2/ show/NCT02398656?term=Coutts&rank=1. Accessed March 26, 2015.
(Stroke. 2015;46:e150. DOI: 10.1161/STROKEAHA.115.009240.) © 2015 American Heart Association, Inc. Stroke is available at http://stroke.ahajournals.org
DOI: 10.1161/STROKEAHA.115.009240
Downloaded from http://stroke.ahajournals.org/ at CMU e150Libraries - library.cmich.edu on September 11, 2015
Response to Letter Regarding Article, ''Tenecteplase−Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke with Proven Occlusion'' Shelagh B. Coutts and Michael D. Hill Stroke. 2015;46:e150; originally published online April 21, 2015; doi: 10.1161/STROKEAHA.115.009240 Stroke is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Copyright © 2015 American Heart Association, Inc. All rights reserved. Print ISSN: 0039-2499. Online ISSN: 1524-4628
The online version of this article, along with updated information and services, is located on the World Wide Web at: http://stroke.ahajournals.org/content/46/6/e150
Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Stroke can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Stroke is online at: http://stroke.ahajournals.org//subscriptions/
Downloaded from http://stroke.ahajournals.org/ at CMU Libraries - library.cmich.edu on September 11, 2015
Response to Letter Regarding Article, “Tenecteplase–Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke with Proven Occlusion”
We thank Dr Behrouz1 for their letter. We are in agreement that further trials of tenecteplase in stroke are needed, but are cautious about making conclusions based on comparisons of noncontemporaneous controls. The Tenecteplase–Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke With Proven Occlusion (TEMPO-2) study2 will examine the effect of tenecteplase versus control among patients with minor stroke and proven intracranial occlusion. We think that it critical to add the element of noninvasive vascular imaging to studies of thrombolytic agents. We are looking forward to beginning the study in the second quarter of 2015.
Acknowledgments Study drug for the TEMPO-1 trial was provided by Hoffman-La Roche Canada.
Disclosures None.
Shelagh B. Coutts, MD, FRCPC Michael D. Hill, MD, FRCPC Departments of Clinical Neurosciences and Radiology Hotchkiss Brain Institute University of Calgary Calgary, Alberta, Canada
1. Behrouz R, Mutgi SA, Silver B. Letter by Behrouz et al regarding article, “Tenecteplase–tissue-type plasminogen activator evaluation for minor ischemic stroke with proven occlusion.” Stroke. 2015;46:e149. doi: 10.1161/STROKEAHA.115.009193. 2. Clinical Trials.gov. A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion (TEMPO-2). Clinical Trials.gov Web site. https://clinicaltrials.gov/ct2/ show/NCT02398656?term=Coutts&rank=1. Accessed March 26, 2015.
(Stroke. 2015;46:e150. DOI: 10.1161/STROKEAHA.115.009240.) © 2015 American Heart Association, Inc. Stroke is available at http://stroke.ahajournals.org
DOI: 10.1161/STROKEAHA.115.009240
Downloaded from http://stroke.ahajournals.org/ at CMU e150Libraries - library.cmich.edu on September 11, 2015
Response to Letter Regarding Article, ''Tenecteplase−Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke with Proven Occlusion'' Shelagh B. Coutts and Michael D. Hill Stroke. 2015;46:e150; originally published online April 21, 2015; doi: 10.1161/STROKEAHA.115.009240 Stroke is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Copyright © 2015 American Heart Association, Inc. All rights reserved. Print ISSN: 0039-2499. Online ISSN: 1524-4628
The online version of this article, along with updated information and services, is located on the World Wide Web at: http://stroke.ahajournals.org/content/46/6/e150
Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Stroke can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Stroke is online at: http://stroke.ahajournals.org//subscriptions/
Downloaded from http://stroke.ahajournals.org/ at CMU Libraries - library.cmich.edu on September 11, 2015
