Pediatric Pulmonology 52:556–569 (2017)
Respiratory Syncytial Virus Hospitalization and Mortality: Systematic Review and Meta-Analysis Renato T. Stein, MD,1 Louis J. Bont, MD,2 Heather Zar, MD,3 Fernando P. Polack, MD,4,5 Caroline Park, PharmD,6 Ami Claxton, PhD,7 Gerald Borok, PhD,7 Yekaterina Butylkova, PharmD,7 and Colleen Wegzyn, PharmD6* Summary. Background: Respiratory syncytial virus (RSV) is a major public health burden worldwide. We aimed to review the current literature on the incidence and mortality of severe RSV in children globally. Methods: Systematic literature review and meta-analysis of published data from 2000 onwards, reporting on burden of acute respiratory infection (ARI) due to RSV in children. Main outcomes were hospitalization for severe RSV-ARI and death. Results: Five thousand two hundred and seventy-four references were identified. Fifty-five studies were included from 32 countries. The global RSV-ARI hospitalization estimates, reported per 1,000 children per year (95% Credible Interval (CrI), were 4.37 (2.98, 6.42) among children
Respiratory Syncytial Virus Hospitalization and Mortality: Systematic Review and Meta-Analysis Renato T. Stein, MD,1 Louis J. Bont, MD,2 Heather Zar, MD,3 Fernando P. Polack, MD,4,5 Caroline Park, PharmD,6 Ami Claxton, PhD,7 Gerald Borok, PhD,7 Yekaterina Butylkova, PharmD,7 and Colleen Wegzyn, PharmD6* Summary. Background: Respiratory syncytial virus (RSV) is a major public health burden worldwide. We aimed to review the current literature on the incidence and mortality of severe RSV in children globally. Methods: Systematic literature review and meta-analysis of published data from 2000 onwards, reporting on burden of acute respiratory infection (ARI) due to RSV in children. Main outcomes were hospitalization for severe RSV-ARI and death. Results: Five thousand two hundred and seventy-four references were identified. Fifty-five studies were included from 32 countries. The global RSV-ARI hospitalization estimates, reported per 1,000 children per year (95% Credible Interval (CrI), were 4.37 (2.98, 6.42) among children
