Acta Cardiologica
ISSN: 0001-5385 (Print) 0373-7934 (Online) Journal homepage: http://www.tandfonline.com/loi/tacd20
Resection of giant mediastinal liposarcoma Kobe Van Bael, Isabelle Claus & Hans Vanoverbeke To cite this article: Kobe Van Bael, Isabelle Claus & Hans Vanoverbeke (2014) Resection of giant mediastinal liposarcoma, Acta Cardiologica, 69:3, 311-312, DOI: 10.1080/AC.69.3.3027835 To link to this article: https://doi.org/10.1080/AC.69.3.3027835
Published online: 23 May 2017.
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Acta Cardiol 2014; 69(3): 311-312
311
doi: 10.2143/AC.69.3.3027835
[ Image focus ]
Resection of giant mediastinal liposarcoma Kobe VAN BAEL, MD; Isabelle CLAUS, MD; Hans VANOVERBEKE, MD Dept. of Cardiothoracic Surgery, ASZ Aalst, Belgium.
Keywords Liposarcoma – mediastinal mass – surgical resection. Diagnostic work out on a 60-year-old male with crescendo dyspnoea revealed a giant mass in the anterior mediastinum of the heart. Complete tumour resection was performed through sternotomy; pathology showed a well differentiated lowgrade liposarcoma. This case emphasizes the importance of including liposarcoma in the differential diagnosis of large
A
mediastinal tumours. Primary mediastinal liposarcoma is an uncommon neoplasm of intrathoracic origin. Complete surgical resection or debulking is the only optimal treatment option and long-term follow-up is recommended because of common recurrence.
CONFLICTING INTERESTS: none declared.
B
Fig. 1 A: a chest X-ray showing widening of the mediastinum with an additional mass presenting on the right side of the heart. B: an axial and sagittal computed tomography image revealing a huge mass in the anterior mediastinum with a soft tissue aspect; preferentially a lipomatous component with extrinsic pressure on the heart and large vessels; pathological lymph nodes were not discovered.
Address for correspondence: Kobe Van Bael, MD, Dept. of Cardiothoracic and Thoracovascular Surgery, ASZ Aalst, Merestraat 80, B-9300 Aalst, Belgium. E-mail: [email protected] Received 17 February 2014; revision accepted for publication 19 March 2014.
312
K. Van Bael et al.
A
B
Fig. 2 The only and primary therapeutic modality was resection of these rare mediastinal liposarcoma. The patient underwent median longitudinal sternotomy. The giant tumoral mass was encapsulated with a thick tunica and seemed to consist of adipose tissue. A: the tumour was completely excised until the anterior pericard and laterally including the parietal pleura on both sides. All surrounding adipose tissue was resected up to the brachiocephalicus vein and until above the phrenic nerve. B: the tumour measured 21 × 14 × 9 cm, had a weight of 1,020 grams and had a soft consistence.
A
B
Fig. 3 Histological feature showed an atypical lipomatous tumour, consistent with a well-differentiated low-graded liposarcoma with amplification of the MDM2 gene on FISH. The tumour revealed primary mature adipocytes with focal lipoblastic mesenchymal cells in a myxoid matrix and thick strands of connective tissue. This network contained atypical stromal cells with a very thick and fibrotic envelope (A-B).
ISSN: 0001-5385 (Print) 0373-7934 (Online) Journal homepage: http://www.tandfonline.com/loi/tacd20
Resection of giant mediastinal liposarcoma Kobe Van Bael, Isabelle Claus & Hans Vanoverbeke To cite this article: Kobe Van Bael, Isabelle Claus & Hans Vanoverbeke (2014) Resection of giant mediastinal liposarcoma, Acta Cardiologica, 69:3, 311-312, DOI: 10.1080/AC.69.3.3027835 To link to this article: https://doi.org/10.1080/AC.69.3.3027835
Published online: 23 May 2017.
Submit your article to this journal
View related articles
View Crossmark data
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=tacd20
Acta Cardiol 2014; 69(3): 311-312
311
doi: 10.2143/AC.69.3.3027835
[ Image focus ]
Resection of giant mediastinal liposarcoma Kobe VAN BAEL, MD; Isabelle CLAUS, MD; Hans VANOVERBEKE, MD Dept. of Cardiothoracic Surgery, ASZ Aalst, Belgium.
Keywords Liposarcoma – mediastinal mass – surgical resection. Diagnostic work out on a 60-year-old male with crescendo dyspnoea revealed a giant mass in the anterior mediastinum of the heart. Complete tumour resection was performed through sternotomy; pathology showed a well differentiated lowgrade liposarcoma. This case emphasizes the importance of including liposarcoma in the differential diagnosis of large
A
mediastinal tumours. Primary mediastinal liposarcoma is an uncommon neoplasm of intrathoracic origin. Complete surgical resection or debulking is the only optimal treatment option and long-term follow-up is recommended because of common recurrence.
CONFLICTING INTERESTS: none declared.
B
Fig. 1 A: a chest X-ray showing widening of the mediastinum with an additional mass presenting on the right side of the heart. B: an axial and sagittal computed tomography image revealing a huge mass in the anterior mediastinum with a soft tissue aspect; preferentially a lipomatous component with extrinsic pressure on the heart and large vessels; pathological lymph nodes were not discovered.
Address for correspondence: Kobe Van Bael, MD, Dept. of Cardiothoracic and Thoracovascular Surgery, ASZ Aalst, Merestraat 80, B-9300 Aalst, Belgium. E-mail: [email protected] Received 17 February 2014; revision accepted for publication 19 March 2014.
312
K. Van Bael et al.
A
B
Fig. 2 The only and primary therapeutic modality was resection of these rare mediastinal liposarcoma. The patient underwent median longitudinal sternotomy. The giant tumoral mass was encapsulated with a thick tunica and seemed to consist of adipose tissue. A: the tumour was completely excised until the anterior pericard and laterally including the parietal pleura on both sides. All surrounding adipose tissue was resected up to the brachiocephalicus vein and until above the phrenic nerve. B: the tumour measured 21 × 14 × 9 cm, had a weight of 1,020 grams and had a soft consistence.
A
B
Fig. 3 Histological feature showed an atypical lipomatous tumour, consistent with a well-differentiated low-graded liposarcoma with amplification of the MDM2 gene on FISH. The tumour revealed primary mature adipocytes with focal lipoblastic mesenchymal cells in a myxoid matrix and thick strands of connective tissue. This network contained atypical stromal cells with a very thick and fibrotic envelope (A-B).
