Photodiagnosis and Photodynamic Therapy (2007) 4, 12 available at www.sciencedirect.com
journal homepage: www.elsevier.com/locate/pdpdt
EDITORIAL
Research and development of photodynamic therapy photosensitizers in China The article presented here by Dr. De-Yu Xu is the latest in a series appearing in Journal of Photodiagnosis and Photodynamic Therapy describing the historical development of various aspects of PDT in different countries around the world. This report looks specifically at how photosensitizers for use in PDT have evolved in China and, due to the fact that much of the data concerning this topic has previously been published only in Chinese language journals, will be of great interest to scientists in western countries who will probably be reading about this for the first time. The article is divided into two main sections covering earlier work on photosensitizer mixtures, thus paralleling development of haematoporphyrin derivative (HpD) in the western world, which eventually led to introduction of the clinical PDT sensitizer PhotofrinTM . In the second section attention is drawn to the synthesis and evaluation of more specific chemical compounds including tetraaryl porphyrins, chlorins, phthalocyanines and non-porphyrinoid sensitizers such as the hypocrellins. While the development of these
1572-1000/$ — see front matter © 2007 Published by Elsevier B.V. doi:10.1016/j.pdpdt.2007.01.004
classes of photosensitizer essentially follows developments in the western countries quite closely, the subtle differences in synthetic methods, purification techniques and absolute structures will be of great interest, generally, to chemists working on porphyrins and their derivatives, and more specifically, those working on PDT sensitizer development. In addition to chemical aspects of PDT sensitizers in China the article also presents a comprehensive summary of physicochemical properties and clinical results relating to these compounds, which represents an important addition to the expanding database available for defining structure activity relationships of photodynamic sensitizers. Ross W. Boyle University of Hull, Department of Chemistry, Cottingham Road, Hull HU6 7RX, United Kingdom E-mail address: [email protected]
journal homepage: www.elsevier.com/locate/pdpdt
EDITORIAL
Research and development of photodynamic therapy photosensitizers in China The article presented here by Dr. De-Yu Xu is the latest in a series appearing in Journal of Photodiagnosis and Photodynamic Therapy describing the historical development of various aspects of PDT in different countries around the world. This report looks specifically at how photosensitizers for use in PDT have evolved in China and, due to the fact that much of the data concerning this topic has previously been published only in Chinese language journals, will be of great interest to scientists in western countries who will probably be reading about this for the first time. The article is divided into two main sections covering earlier work on photosensitizer mixtures, thus paralleling development of haematoporphyrin derivative (HpD) in the western world, which eventually led to introduction of the clinical PDT sensitizer PhotofrinTM . In the second section attention is drawn to the synthesis and evaluation of more specific chemical compounds including tetraaryl porphyrins, chlorins, phthalocyanines and non-porphyrinoid sensitizers such as the hypocrellins. While the development of these
1572-1000/$ — see front matter © 2007 Published by Elsevier B.V. doi:10.1016/j.pdpdt.2007.01.004
classes of photosensitizer essentially follows developments in the western countries quite closely, the subtle differences in synthetic methods, purification techniques and absolute structures will be of great interest, generally, to chemists working on porphyrins and their derivatives, and more specifically, those working on PDT sensitizer development. In addition to chemical aspects of PDT sensitizers in China the article also presents a comprehensive summary of physicochemical properties and clinical results relating to these compounds, which represents an important addition to the expanding database available for defining structure activity relationships of photodynamic sensitizers. Ross W. Boyle University of Hull, Department of Chemistry, Cottingham Road, Hull HU6 7RX, United Kingdom E-mail address: [email protected]
